“诊疗一体化”是目前疾病诊断和治疗的一个发展趋势。利用纳米材料在物理、化学、生物等方面展现的特殊性质，构建以纳米材料为基础的诊断与治疗相融合的疾病诊疗体系是目前医疗领域的研究热点。普鲁士蓝纳米颗粒结构稳定，具有独特的光学、酶学、磁学等性质，且具有良好的生物安全性。近年来，普鲁士蓝纳米颗粒在药物负载、拉曼成像、光声成像、清除活性氧、光热治疗等方面发挥着重要的疾病诊疗作用，受到科研人员的广泛关注。
阿拉丁提供分散性良好、稳定、表面功能化、低毒的普鲁士蓝纳米颗粒，可用于抗氧化、肿瘤磁共振成像、肿瘤光热治疗等，搭建疾病诊疗一体化平台。
产品名称
| 柠檬酸修饰的普鲁士蓝纳米颗粒
|
水动力尺寸
| 94 nm
|
表面修饰分子
| 柠檬酸
|
溶剂
| 超纯水
|
浓度
| 1 mg/mL |
产品参数
1. 水动力尺寸统计图
水动力尺寸约为 94 nm。
图1：普鲁士蓝纳米颗粒的水动力尺寸统计图
2. Zeta 电位
Zeta 电位约为-50 mV。
3. 电镜图
图2：普鲁士蓝纳米颗粒的 TEM 电镜图
4. 紫外-可见吸收光谱
普鲁士蓝纳米颗粒在700 nm左右有特征吸收。
图3：普鲁士蓝纳米颗粒的紫外-可见吸收光谱图
使用效果
实验证明普鲁士蓝纳米颗粒 (PBNPs)具有类过氧化物酶、过氧化氢酶、SOD 酶等多酶活性，能够有效清除自由基。
实验结果验证了 PBNPs 可以保护细胞免受紫外（UVA）、二烯丙基三硫（DATS）、脂多糖（LPS）、佛波酯（PMA）、高糖等培养环境引起的自由基损伤，并且可以保护神经海马细胞在 OGD 复氧过程中的损伤，提示 PBNPs 是一种潜在的清除 ROS、抗氧化、抗炎以及脑部缺血再灌注损伤保护剂。
使用 LPS 建立的动物肝炎模型验证了 PBNPs 在小鼠体内累积在肝和脾，并可以有效地保护小鼠肝脏免受 LPS 诱导产生肝部炎症。
普鲁士蓝纳米颗粒还具有光热效应，可用于光热治疗以及光声成像领域；通过掺杂钆元素还能实现磁共振成像；具有特征拉曼信号，可用于拉曼成像；还能作为药物载体，构建纳米药物递送系统。
注意事项
普鲁士蓝纳米颗粒在使用和保存过程中应避免冻融。
普鲁士蓝纳米颗粒在碱性条件（pH > 7）下易分解。
Theranostics is a major developmental trend in modern disease diagnosis and treatment. By utilizing the unique physical, chemical and biological properties of nanomaterials, constructing nanomaterial-based integrated systems that combine diagnosis and therapy has become a core research hotspot in the medical field. Prussian blue nanoparticles feature stable structure, along with distinctive optical, enzymatic and magnetic properties and excellent biosafety. In recent years, Prussian blue nanoparticles have played critical roles in drug loading, Raman imaging, photoacoustic imaging, reactive oxygen species scavenging, photothermal therapy and other theranostic applications, attracting widespread attention from scientific researchers.
Aladdin provides well-dispersed, stable, surface-functionalized and low-toxic Prussian blue nanoparticles. These products can be applied to antioxidation, tumor magnetic resonance imaging, tumor photothermal therapy and other scenarios, supporting the construction of integrated disease theranostic platforms.
Product Name
| Citrate-modified Prussian Blue Nanoparticles
|
Hydrodynamic Size
| 94 nm
|
Surface Modifier
| Citrate
|
Solvent
| Ultrapure Water
|
Concentration
| 1 mg/mL |
Product Parameters
- Hydrodynamic Size DistributionThe average hydrodynamic size is approximately 94 nm.
Figure 1 Hydrodynamic size distribution of Prussian blue nanoparticles
2. Zeta PotentialZeta potential: approximately -50 mV
3. Electron Micrograph
Figure 2 TEM micrograph of Prussian blue nanoparticles
4. UV-Vis Absorption Spectrum
Prussian blue nanoparticles show characteristic absorption at around 700 nm.
Figure 3 UV-Vis absorption spectrum of Prussian blue nanoparticles
Functional Performance
Experiments have confirmed that Prussian blue nanoparticles possess multi-enzyme mimetic activities, including peroxidase-like, catalase-like and SOD-like activities, and can scavenge free radicals efficiently.
Experimental results verify that PBNPs can protect cells from free radical damage induced by UVA irradiation, diallyl trisulfide (DATS), lipopolysaccharide (LPS), phorbol myristate acetate (PMA) and high-glucose culture environments. They can also alleviate the injury of hippocampal neuronal cells caused by oxygen-glucose deprivation and reoxygenation. It indicates that PBNPs are promising agents for ROS scavenging, antioxidation, anti-inflammation and cerebral ischemia-reperfusion injury protection.
In an LPS-induced hepatitis animal model, PBNPs were observed to accumulate in the liver and spleen of mice, and effectively protect the liver from LPS-triggered inflammatory damage.
Prussian blue nanoparticles also have outstanding photothermal effects for photothermal therapy and photoacoustic imaging. Gadolinium doping enables them to achieve magnetic resonance imaging functions. Their unique characteristic Raman signals support Raman imaging applications. Furthermore, they can serve as drug carriers to construct nano drug delivery systems.
Precautions
- Freeze-thaw cycles must be avoided during the use and storage of Prussian blue nanoparticles.
- Prussian blue nanoparticles are susceptible to decomposition under alkaline conditions (pH > 7).
ZJ26F0838445
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