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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
烟酰胺腺嘌呤二核苷酸（NAD）是所有细胞中都存在的一种辅酶，包括氧化型（NAD⁺）和还原型（NADH）两种形式。NAD⁺不仅作为氧化还原反应中传递电子的辅酶，还可作为多种酶的底物参与细胞内反应。NAD⁺在细胞与生物体内发挥重要功能，其合成与降解及其产物参与细胞凋亡、代谢调控和基因表达等过程，NAD⁺的减少是细胞死亡的主要因素之一。NAD⁺在调节细胞氧化还原状态以及调控信号通路与转录方面的重要性，使其本身及其合成与消耗相关酶成为多种疾病的潜在药物靶点。 本试剂盒的检测原理基于酶循环反应（不识别NADP⁺/NADPH），该反应过程中NAD⁺被还原为NADH，NADH进一步将WST-8还原生成橙黄色的甲臜（formazan），该产物在约450 nm处具有最大吸收峰。反应体系中生成的甲臜量与样品中总的NAD⁺或NADH含量呈正比。
Nicotinamide adenine dinucleotide (NAD) is a coenzyme present in all living cells, existing in two forms: the oxidized form (NAD⁺) and the reduced form (NADH). NAD⁺ not only functions as a coenzyme in electron transfer during redox reactions but also serves as a substrate for various enzymes in intracellular reactions. NAD⁺ plays essential roles in cells and organisms; its synthesis, degradation, and metabolic products are involved in processes such as apoptosis, metabolic regulation, and gene expression. Depletion of NAD⁺ is a major factor in cell death. The importance of NAD⁺ in regulating cellular redox status, as well as in modulating signaling pathways and transcription, has made NAD⁺ itself and its synthesis and consumption-related enzymes potential drug targets for various diseases. This kit is based on an enzymatic cycling reaction (which does not recognize NADP⁺/NADPH). In this reaction, NAD⁺ is reduced to NADH, which subsequently reduces WST-8 to form an orange-yellow formazan product with a maximum absorbance peak at approximately 450 nm. The amount of formazan generated in the reaction system is proportional to the total NAD⁺ or NADH content in the sample.
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