| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C408591-1ml |
1ml |
现货  |
|
| 规格或纯度 | Moligand™, 10mM in DMSO | ||||||
|---|---|---|---|---|---|---|---|
| 英文名称 | Clofibrate | ||||||
| 生化机理 | 氯贝特（Atromid-S）是一种纤维酸衍生物，用于治疗 III 型高脂蛋白血症和严重的高甘油三酯血症。氯贝特能提高肝外脂蛋白脂肪酶（LL）的活性，从而增加脂蛋白甘油三酯的脂肪分解。乳糜微粒被降解，VLDLs 转化为 LDLs，LDLs 转化为 HDL。与此同时，分泌到胆汁并最终进入肠道的脂质也会略有增加。氯贝特还能抑制载脂蛋白 B（VLDL 的载体分子）的合成并增加其清除率。[1] '} |
||||||
| 储存温度 | -80℃储存 | ||||||
| 运输条件 | 超低温冰袋运输 | ||||||
| 作用类型 | 激动剂 | ||||||
| 作用机制 | 过氧化物酶体增殖激活受体 alpha 激动剂 | ||||||
| 产品介绍 |
Information Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. In vivo
cell lines： Concentrations： Incubation Time： Powder Purity:≥99% |
||||||
| ALogP | 3.329 |
|---|---|
| hba_count | 3 |
| Rotatable Bond | 5 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CCOC(=O)C(C)(C)OC1=CC=C(Cl)C=C1 |
| 分子量 | 242.7 |
| Reaxy-Rn | 1913459 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1913459&ln= |
| DMSO(mg / mL) Max Solubility | 7 |
|---|---|
| DMSO(mM) Max Solubility | 28.84 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 1913459 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1913459&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Cancan Duan, Weina Cheng, Qihong Chen, Xiaofei Li, Jianyong Zhang. (2021) Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats. BIOMEDICAL CHROMATOGRAPHY, 35 (10): (e5172). [PMID:33982312] [10.1002/bmc.5172] |
| 1. Cancan Duan, Weina Cheng, Qihong Chen, Xiaofei Li, Jianyong Zhang. (2021) Pharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats. BIOMEDICAL CHROMATOGRAPHY, 35 (10): (e5172). [PMID:33982312] [10.1002/bmc.5172] |
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