| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| C408961-1ml |
1ml |
现货  |
|
| 英文别名 | CFTR inhibitor 172 | Benzoic acid, 4-[[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]- |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | CFTRinh-172 |
| 生化机理 | CFTRinh-172 （CFTR 抑制剂 172）是一种与电压无关的选择性 CFTR 抑制剂，Ki为 300 nM，对 MDR1、ATP 敏感的 K+ 通道或一系列其他转运体没有影响。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
产品应用： Information CFTRinh-172 CFTRinh-172 (CFTR inhibitor 172) is a voltage-independent, selective CFTR inhibitor with K i of 300 nM, showing no effects on MDR1, ATP-sensitive K+ channels, or a series of other transporters. CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl− current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition. In vivo CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo. cell lines：Rheumatoid arthritis synovial fibroblast(s) Concentrations：~1 mM Incubation Time：24 hours Powder Purity:≥99% |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | OC(=O)C1=CC=C(C=C1)\C=C/2SC(=S)N(C2=O)C3=CC=CC(=C3)C(F)(F)F |
| 分子量 | 409.4 |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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