计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
Ciclopirox, 铝螯合剂
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Information
Ciclopirox Ciclopirox is a broad-spectrum antifungal agent working as an iron chelator .
In vitro
Ciclopirox olamine (CPX) is a lipophilic bidentate iron chelator that stabilizes HIF-1alpha under normoxic conditions at lower concentrations than other iron chelators, probably by inhibiting HIF-1alpha hydroxylation. Ciclopirox olamine (CPX)-induced HIF-1 mediates reporter gene activity and endogenous HIF-1 target gene expression, including elevation of transcription, mRNA, and protein levels of the vascular endothelial growth factor (VEGF). Ciclopirox inhibits growth of C. albicans yeast and hyphal cells in a dose-dependent manner. Ciclopirox blocks H2O2-induced mitochondrial injury by maintaining mitochondrial transmembrane potential (Deltapsim). Ciclopirox completely blocks H2O2-stimulated release of lactate dehydrogenase (a marker of cell death) and decreases in MTT reduction (a marker of mitochondrial function) in adenocarcinoma SK-HEP-1 cells. Ciclopirox effectively inhibits H2O2-induced mitochondrial permeability transition pore (MPTP) opening. Ciclopirox increases the MTP, maintained it high, and blocks the ATP depletion in glucose-deprived SIN-1-treated astrocytes. Ciclopirox protects astrocytes from peroxynitritecytotoxicity by attenuating peroxynitrite-induced mitochondrial dysfunction. Ciclopirox is a substituted pyridone antimycotic drug, unrelated to the imidazole derivatives and its topical application ensures maximum local bioavailability. Ciclopirox acts on fungi by inhibiting the intracellular uptake of essential substrates and ions and this probably acts on the Candida ability to express its adherence mechanisms.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
别名
环吡酮
英文别名
6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone
规格或纯度
Moligand™, 10mM in DMSO
英文名称
Ciclopirox
生化机理
环吡酮胺是一种广谱抗真菌剂，具有铁螯合剂的作用。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
作用机制
铝螯合剂
名称和识别符
EC号
249-577-2
分子类型
小分子
Isomeric SMILES
CC1=CC(=O)N(C(=C1)C2CCCCC2)O
分子量
207.27
Reaxy-Rn
1533423
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1533423&ln=
技术文档
高级数据
产品属性
| ALogP | 2 |
|---|
关联靶点（人）
PARP1
Tclin
聚[ADP-核糖]聚合酶1(Poly [ADP-ribose] polymerase 1)
(0 活性数据)
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 2 mg/mL (3.09 mM); Water: Insoluble; Ethanol: Insoluble;
安全和危险性（GHS）
信号词
警告
危险声明
H302: 吞食有害
H312: 皮肤接触有害
H319: 引起严重眼睛刺激
H332: 吸入有害
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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