计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 34 篇同行评审文献引用。
概述
生化研究，保健品等。
Product Application：
Creatine is involved in the rapid production of ATP associated with creatine kinases in skeletal muscle tissue.Creatine may be used as a supplement to study its mechanism of action. It acts as a nutraceutical and a neuroprotective agent.
规格
别名
N-甲基胍基乙酸 | 无水肌酸 | 2-(1-甲基胍基)乙酸 | N-脒基肌氨酸 | N-胺肉胺酸 | α-甲胍乙酸
英文别名
2-[carbamimidoyl(methyl)amino]acetic acid | bmse000078 | Kreatinum | Methylguanidoacetate | [[Amino(imino)methyl](methyl)amino]acetic acid | STR05570 | FT-0624083 | N-(aminoiminomethyl)-N-methylglycine | N-(Aminoiminomethyl)-N-methyl-glycine | (a-Methylgu
规格或纯度
Moligand™, 10mM in Water
英文名称
Creatine
生化机理
肌酸是一种含氮化合物，可充当 ATP 快速再生的高能量储存库。大约 95% 的肌酸存在于骨骼肌中，主要为磷酸肌酸。肌酸可通过饮食摄入，也可由 L-精氨酸、甘氨酸和 L-蛋氨酸在肾脏和肝脏发生的多步骤反应中形成。肌酸随后被转运至肌肉组织。肌酸补充剂主要通过增加肌肉质量来增强运动成绩。肌酸还被研究用于神经肌肉疾病的治疗，可能有助于神经保护和改善细胞生物能量状态。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
PubChem SID
EC号
200-306-6
分子类型
小分子
IUPAC Name
2-[carbamimidoyl(methyl)amino]acetic acid
INCHI
1S/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H3,5,6)(H,8,9)
InChi Key
CVSVTCORWBXHQV-UHFFFAOYSA-N
Smiles
CN(CC(=O)O)C(=N)N
Isomeric SMILES
CN(CC(=O)O)C(=N)N
分子量
131.13
Beilstein号
907175
Reaxy-Rn
907175
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=907175&ln=
技术文档
高级数据
系统学分类
分类树（Taxonomy Tree）
| 界（kingdom) | 有机化合物 |
|---|---|
| 超类（Superclass) | 有机酸及其衍生物 |
| 类（Class) | 羧酸及其衍生物 |
| 亚类（Subclass） | 氨基酸、肽和类似物 |
| 中间层级节点（Intermediate Tree Nodes） | 氨基酸及其衍生物 |
| 直接上位类(Direct Parent) | α氨基酸及其衍生物 |
| 其他上位类（Alternative Parents） | 胍类 一元羧酸及其衍生物 羧酸 甲脒类 有机光子化合物 有机氧化物 亚胺 碳氢化合物衍生物 羰基化合物 |
| 分子骨架（Molecular Framework) | 脂肪族无环化合物 |
| 取代基（Substituents） | 脂肪族非环化合物 - α-氨基酸或其衍生物 - 羰基 - 羧酰亚胺 - 羧酰胺基 - 胍 - 烃衍生物 - 亚胺 - 单羧酸或其衍生物 - 有机硝基化合物 - 有机氧化物 - 有机氧化合物 - 有机氮化合物 - 有机氧化合物 - 有机氮化合物 |
| 描述（Description） | 该化合物属于有机化合物中的α-氨基酸及其衍生物类。此类氨基酸的氨基直接连接于羧基相邻的碳原子（α-碳），或其衍生物。 |
| 外部描述符（External Descriptors） | glycine derivative - guanidines |
三维结构
交互式化学结构模型
关联靶点（人）
F2
Tclin
Thrombin
(11687 活性数据)
ESR1
Tclin
Estrogen receptor alpha
(17718 活性数据)
PGR
Tclin
Progesterone receptor
(8562 活性数据)
CHRM2
Tclin
Muscarinic acetylcholine receptor M2
(10671 活性数据)
HTR1A
Tclin
Serotonin 1a (5-HT1a) receptor
(14969 活性数据)
ADRA2A
Tclin
Alpha-2a adrenergic receptor
(9450 活性数据)
AR
Tclin
Androgen Receptor
(11781 活性数据)
CHRM1
Tclin
Muscarinic acetylcholine receptor M1
(12690 活性数据)
MAOA
Tclin
Monoamine oxidase A
(11911 活性数据)
DRD1
Tclin
Dopamine D1 receptor
(9720 活性数据)
ACHE
Tclin
Acetylcholinesterase
(18204 活性数据)
PTGS1
Tclin
Cyclooxygenase-1
(9233 活性数据)
SLC6A2
Tclin
Norepinephrine transporter
(10102 活性数据)
SLC6A4
Tclin
Serotonin transporter
(12625 活性数据)
ADRA1A
Tclin
Alpha-1a adrenergic receptor
(8359 活性数据)
OPRM1
Tclin
Mu opioid receptor
(19785 活性数据)
DRD3
Tclin
Dopamine D3 receptor
(14368 活性数据)
SLC6A3
Tclin
Dopamine transporter
(10535 活性数据)
KCNH2
Tclin
HERG
(29587 活性数据)
PDE3A
Tclin
Phosphodiesterase 3A
(3309 活性数据)
HTR2B
Tclin
Serotonin 2b (5-HT2b) receptor
(10323 活性数据)
TBXA2R
Tclin
Thromboxane A2 receptor
(5717 活性数据)
PDE4A
Tclin
Phosphodiesterase 4A
(1943 活性数据)
ADORA3
Tchem
Adenosine A3 receptor
(15931 活性数据)
HRH3
Tclin
Histamine H3 receptor
(10389 活性数据)
KDR
Tclin
Vascular endothelial growth factor receptor 2
(20924 活性数据)
CKM
Tbio
Creatine kinase M
(67 活性数据)
SLC36A1
Tchem
Proton-coupled amino acid transporter 1
(102 活性数据)
SLC6A8
Tbio
Sodium- and chloride-dependent creatine transporter 1
(1 活性数据)
关联靶点（其它种属）
Hdac6
Histone deacetylase 6 (222 活性数据)
rep
Replicase polyprotein 1ab (378 活性数据)
Slc22a5
Solute carrier family 22 member 5 (44 活性数据)
SARS-CoV-2 (38078 活性数据)
作用机制
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
化学和物理性质
熔点
290°C
分子量
131.130 g/mol
XLogP3
-1.200
氢键供体数Hydrogen Bond Donor Count
3
氢键受体数Hydrogen Bond Acceptor Count
3
可旋转键计数Rotatable Bond Count
3
精确质量Exact Mass
131.069 Da
单同位素质量Monoisotopic Mass
131.069 Da
拓扑极表面积Topological Polar Surface Area
90.400 Ų
重原子数Heavy Atom Count
9
形式电荷Formal Charge
0
复杂度Complexity
134.000
同位素原子数Isotope Atom Count
0
定义的原子立体中心计数Defined Atom Stereocenter Count
0
未定义的原子立体中心计数Undefined Atom Stereocenter Count
0
定义的键立体中心计数Defined Bond Stereocenter Count
0
未定义的键立体中心计数Undefined Bond Stereocenter Count
0
所有立体化学键的总数The total count of all stereochemical bonds
0
共价键合单元计数Covalently-Bonded Unit Count
1
安全和危险性（GHS）
WGK Germany
3
Merck Index
2568
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 K2201198 |
分析证书 | C424813 |
技术文档和文章
此产品的引用文献
引用文献
| 1. Xinzhao Jiang, Wei Wang, Jincheng Tang, Meng Han, Yichang Xu, Lichen Zhang, Jie Wu, Yiyang Huang, Zhouye Ding, Huiwen Sun, Kun Xi, Yong Gu, Liang Chen. (2023) Ligand-Screened Cerium-Based MOF Microcapsules Promote Nerve Regeneration via Mitochondrial Energy Supply. Advanced Science, [PMID:38037294] [10.1002/advs.202306780] |
| 2. Xueping Quan, Bing Yan. (2023) In Situ Generated Dye@MOF/COF Heterostructure for Fluorescence Detection of Chloroquine Phosphate and Folic Acid via Different Luminescent Channels. ACS Applied Materials & Interfaces, [PMID:37972380] [10.1021/acsami.3c11298] |
| 3. Wei Jia, Jiying Zhu. (2023) Molecular Mechanism of ε-Polylysine Treatment of Animal-Derived Foods: Glycine Amidinotransferase Activity Implicates Upregulation of l-Arginine and Creatine. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:37793042] [10.1021/acs.jafc.3c04033] |
| 4. Wei Jia, Xin Wang. (2023) 3-Chloropropane-1,2-diol exposure adversely influenced the bio-accessibility signatures of digested infant foods by suppressing the destabilization of α-lactalbumin and d-aspartate oxidase in a dose-dependent manner. FOOD CHEMISTRY, [PMID:37385056] [10.1016/j.foodchem.2023.136729] |
| 5. Xu Zhang, Xiaotong Wang, Rui Shi, Xiaoku Ran, Xiahong He, Deqiang Dou. (2023) Effective substances and mechanism of red ginseng on rats with spleen-deficiency syndrome based on the substance and energy metabolism as well as the “brain-gut” axis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37003398] [10.1016/j.jep.2023.116438] |
| 6. Bushra Rafique, Rizwan Ullah Khan, Aysha Sarfraz Rizvi, Muhammad Irfan, Ghulam Murtaza, Lili Qiu, Min Xue, Zihui Meng. (2023) Creatinine Imprinted Photonic Crystals Hydrogel Sensor. Arabian Journal of Chemistry, [10.1016/j.arabjc.2023.104684] |
| 7. Haifeng Sha, Bing Yan. (2023) Terbium-based metal-organic frameworks through energy transfer modulation for visual logical sensing zinc and fluorine ions. TALANTA, [PMID:36801562] [10.1016/j.talanta.2023.124326] |
| 8. Lang Zhang, Yingying Hu, Qian Liu, Qian Chen, Xiufang Xia, Baohua Kong. (2022) Cyanidin and rutin inhibit the formation of heterocyclic aromatic amines in chemical modeling systems and smoked chicken drumsticks. FOOD CHEMISTRY, [PMID:35964565] [10.1016/j.foodchem.2022.133869] |
| 9. Lang Zhang, Xiufang Xia, Fangda Sun, Haotian Liu, Qian Chen, Baohua Kong. (2022) Inhibitory effects of hydrocolloids on the formation of heterocyclic aromatic amines in smoked chicken drumsticks and the underlying mechanism. FOOD HYDROCOLLOIDS, [10.1016/j.foodhyd.2022.107940] |
| 10. Yu-Fei Zhong, Guang-Ming Bao, Mei Qiu, Yi-Fan Xia, Wei Li, Ying-Qing Tao, Si-Yi Liu, Si-Han Li, Wei Xiao, Yongfan Zhang, Hou-Qun Yuan. (2022) Highly selective and sensitive fluorescent biosensor for the detection of serotonin and its metabolite by Eu3+-Doped Metal-Organic framework. CHEMICAL ENGINEERING JOURNAL, [10.1016/j.cej.2022.136272] |
| 11. Nian Cao, Faqiong Zhao, Baizhao Zeng. (2019) A novel self-enhanced electrochemiluminescence sensor based on PEI-CdS/Au@SiO2@RuDS and molecularly imprinted polymer for the highly sensitive detection of creatinine. SENSORS AND ACTUATORS B-CHEMICAL, [10.1016/j.snb.2019.127591] |
| 12. Xueying Liu, Xiaoku Ran, Muhammad Riaz, Haixue Kuang, Deqiang Dou, Decheng Cai. (2019) Mechanism Investigation of Tagetes patula L. against Chronic Nonbacterial Prostatitis by Metabolomics and Network Pharmacology. MOLECULES, 24 (12): (2266). [PMID:31216740] [10.3390/molecules24122266] |
| 13. Xianzhi Jiao, Yaoyong Meng, Kangkang Wang, Wei Huang, Nan Li, Timon Cheng-Yi Liu. (2019) Rapid Detection of Adulterants in Whey Protein Supplement by Raman Spectroscopy Combined with Multivariate Analysis. MOLECULES, 24 (10): (1889). [PMID:31100965] [10.3390/molecules24101889] |
| 14. Rao Hanbing, Lu Zhiwei, Ge Hongwei, Liu Xin, Chen Bingyao, Zou Ping, Wang Xianxiang, He Hua, Zeng Xianyin, Wang Yanying. (2016) Electrochemical creatinine sensor based on a glassy carbon electrode modified with a molecularly imprinted polymer and a Ni@polyaniline nanocomposite. MICROCHIMICA ACTA, 184 (1): (261-269). [10.1007/s00604-016-1998-x] |
| 15. Tingting Wen, Wanying Zhu, Cheng Xue, Jinhua Wu, Qing Han, Xi Wang, Xuemin Zhou, Huijun Jiang. (2014) Novel electrochemical sensing platform based on magnetic field-induced self-assembly of Fe3O4@Polyaniline nanoparticles for clinical detection of creatinine. BIOSENSORS & BIOELECTRONICS, [PMID:24487254] [10.1016/j.bios.2014.01.013] |
| 16. Tao Hu, Ji-Na Hao, Yongsheng Li. (2024) A highly luminescent lanthanide-functionalized covalent organic framework for rapid and specific detection of 7-methylguanine for DNA methylation assessment. Biomaterials Science, 12 (20): (5266-5273). [PMID:39238274] [10.1039/D4BM01018C] |
| 17. Yang Liu, Guiliang Li, Qiu Han, Haibo Lin, Qiang Li, Gang Deng, Fu Liu. (2024) Cu (II)-phenolic complex incorporated hemodialysis membranes for efficient urea removal via enhanced adsorption strategy. JOURNAL OF MEMBRANE SCIENCE, [10.1016/j.memsci.2024.122480] |
| 18. Zhiyang Deng, Qing Zhang, Piaopiao Long, Mingchun Wen, Zisheng Han, Daniel Granato, Jun Qi, Liang Zhang, Mengting Zhu. (2024) Effects of green tea and its polyphenols on the formation of heterocyclic aromatic amines, antioxidant capacity, and quality characteristics of roasted pork patties. Applied Food Research, [10.1016/j.afres.2024.100606] |
| 19. Lei Xie, Tianxing Wang, Ling Chen, Xiaoxi Li. (2024) Effects of myricetin on heterocyclic aromatic amines formation and sensory quality of Cantonese mooncakes. FOOD CHEMISTRY, [PMID:39577259] [10.1016/j.foodchem.2024.142084] |
| 20. SunHongzheng , HanLongsen , GuoYueshuai , AnHuiqing , WangBing , ZhangXiangzheng , LiJiashuo , JiangYingtong , WangYue , SunGuangyi , ZhuShuai , TangShoubin , GeJuan , ChenMinjian , GuoXuejiang , WangQiang. (2024) The global phosphorylation landscape of mouse oocytes during meiotic maturation. EMBO JOURNAL, [PMID:39256562] [10.1038/s44318-024-00222-1] |
| 21. Cheng Hu, Jia-Qi Zhang, Xiao-Yu Zhuang, Zhen-Duo Zhao, Xiao-Jing Qian, Ying Chen. (2025) The hidden potential of solasonine: Targeting non-small cell lung cancer (NSCLC) metastasis through GATM and Smad2 pathways. PHYTOMEDICINE, [PMID:39922150] [10.1016/j.phymed.2025.156455] |
| 22. Jinmin Wang, Xianglong Qu, Limin Zhao, Bing Yan. (2021) Fabricating Nanosheets and Ratiometric Detection of 5-Fluorouracil by Covalent Organic Framework Hybrid Material. ANALYTICAL CHEMISTRY, [PMID:33616391] [10.1021/acs.analchem.0c05309] |
| 23. Xinrong Jiang, Xiaoming Chen, Tao Wang, Yuexin Li, Aiwu Pan, Jianmin Wu. (2020) Perfluorinated polymer modified vertical silicon nanowires as ultra low noise laser desorption ionization substrate for salivary metabolites profiling. TALANTA, [PMID:33592752] [10.1016/j.talanta.2020.122022] |
| 24. Hao-Hua Deng, Hua-Ping Peng, Kai-Yuan Huang, Shao-Bin He, Qiao-Feng Yuan, Zhen Lin, Rui-Ting Chen, Xing-Hua Xia, Wei Chen. (2019) Self-Referenced Ratiometric Detection of Sulfatase Activity with Dual-Emissive Urease-Encapsulated Gold Nanoclusters. ACS Sensors, [PMID:30652857] [10.1021/acssensors.8b01130] |
| 25. Longwei Jiang, Iftikhar Hussain Badar, Ziwen Yang, Guanhua Li, Yingying Hu, Lang Zhang. (2025) Effect of different roasting time on the formation of free and bound heterocyclic aromatic amines in roasted beef. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [10.1016/j.jfca.2025.107488] |
| 26. Hongming Hou, Yifan Liu, Xianglong Li, Wenbo Liu, Xiaoli Gong. (2024) Rapid electrodeposition of Cu nanoparticle film on Ni foam as an integrated 3D free-standing electrode for non-invasive and non-enzymatic creatinine sensing. ANALYST, 149 (10): (2905-2914). [PMID:38572989] [10.1039/D4AN00162A] |
| 27. Hui Liu, Yi-Wei Liu, Ruo-Yu Yang, Mei-Juan Wu, Zi-Wei Yu, Jing-Wen Han, Chen-Zhi Zhang, Pin-Fang Huang, Ai-Lin Liu, Meng-Meng Liu. (2024) Therapeutic Drug Monitoring of Methotrexate by Disposable SPCE Biosensor for Personalized Medicine. ANALYTICA CHIMICA ACTA, [PMID:39643323] [10.1016/j.aca.2024.343473] |
| 28. Guoli Chen, Ji-Na Hao, Yongsheng Li. (2025) Sensitive and fast assessment of DNA methylation degree by a luminescent lanthanide-functionalized MOF probe. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2025.114469] |
| 29. Yun Luo, Fanbin Hu, Le Tian, Qingfeng Liu, Yi Fan, Yingjie Zhang, Zitong Fei, Qi Meng, Peng Dong. (2025) Efficient Direct Regeneration of Spent LiFePO4 Cathodes via Molecular Fencing and Vapor Deposition. ADVANCED FUNCTIONAL MATERIALS, [10.1002/adfm.202512637] |
| 30. Hongmei Gao, Yourong Zhao, Yuhong Xie, Yiying Wang, Jie Che, Daojiang Gao, Zhanglei Ning. (2025) A Ratiometric Fluorescent Probe Based on CDs-Functionalized UiO-66 for Efficient Detection of Uric Acid. Chemosensors, 13 (9): (340). [10.3390/chemosensors13090340] |
| 31. Yongsheng Zheng, Kai You, Cuiping Guo, Zhijie Geng, Yuwei Gao, Zhaoming Liu, Dong Yang, Huilong Guo, Jun Huang. (2025) Reuterin integrated as dynamic imine crosslinks strengthens creatine modified chitosan hydrogel and boosts antibacterial efficacy. CARBOHYDRATE RESEARCH, [PMID:41145033] [10.1016/j.carres.2025.109716] |
| 32. Hou Hongming, Long Jiajun, Li Xianglong. (2025) Cu nanoparticles regulated by sodium lignosulfonate-Cu2+ chelation for highly sensitive non-enzymatic creatinine sensing. MICROCHIMICA ACTA, 192 (12): (830). [PMID:41264037] [10.1007/s00604-025-07689-7] |
| 33. Hongming Hou, Xiaoxue Liang, Xianglong Li. (2026) A multi-morphological cu modified electrode for sensitive non-enzymatic creatinine detection. MICROCHEMICAL JOURNAL, [10.1016/j.microc.2026.117727] |
| 34. Mai Quan-Doan, Dang Thi Hanh Trang, Tran Van Tiep, Ngo Thi Loan, Ong Van Hoang, Cao Thi Hong, Nguyen Quang Hoa, Lich Le Van, Nguyen Cong Chi, Mai Xuan Trang, Phan Manh-Huong, Pham Anh-Tuan, Le Anh-Tuan. (2026) Synergistic Plasmonic-Molecular Recognition in Porous Multicore@Shell Ag@UiO-66 Nanostructures toward Selective and Ultrasensitive SERS Detection of Salicylic Acid. LANGMUIR, 42 (29): (21139-21154). [PMID:42443117] [10.1021/acs.langmuir.6c01767] |
溶液计算器
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