计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-20°C储存。超低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CTX-471 is a fully human monoclonal antibody of CD137 . CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer
In Vitro
CTX-471 (5-500 nM) has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 binds to a unique epitope on CD137. CTX-471 (0.1-100 nM; 1, 10 μg/mL; 3 days) increases IFN-y production by human T cells in an Fcy receptor-dependent (FcyR-dependent) manner in vitro. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CTX-471 (i.p.; 150 μg) exhibits curative monotherapy activity in various syngeneic tumor models and shows a unique ability to cure mice of very large tumors.\nCTX-471 (i.v.; 10-80 mg/kg; on days 0, 7, 14, and 21) is well tolerated, with no signs of hepatic toxicity in high doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: BALB/c mice Dosage: 150 μg; 10-80 mg/kg Administration: i.p., on days 6, 9, 12, 19 and 26( or on days 7, 10, 13, 20, and 27 or on days 0, 3, 6, and 9); i.v., on days 0, 7, 14, and 21 Result: Required T and NK cells, as well as FcγR engagement to achieve its efficacy. Do not induce hepatic inflammation.
Form:Liquid
IC50& Target:Kd for CD137: 50 nM (human),61 nM (cynomolgus macaque),748 nM (mouse)
规格
英文名称
CTX-471
生化机理
CTX-471 是一种全人源的 CD137 单克隆抗体。CTX-471 与重组人、猕猴 CD137 和小鼠 CD137 的结合亲和力 K d 值分别为 50 nM、61 nM 和 748 nM。CTX-471 可用于免疫调节药物的研究。
储存条件
-20°C储存
运输条件
超低温运输
名称和识别符
分子类型
小分子
Smiles
[3H][C][X471]
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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