计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC 50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion.
In Vitro
CAY10650 (12 nM; 30 min; neutrophils) inhibits the expression of the phosphorylated cPLA2-α (p-cPLA2-α) in cells. CAY10650 (12 nM; 2 h; neutrophils) inhibits PGE2 release in neutrophils. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Neutrophils Concentration: 12 nM Incubation Time: 30 minutes Result: Inhibited cPLA2-α and inhibited the expression of the p-cPLA2-α. Western Blot AnalysisCell Line: Neutrophils Concentration: 12 nM Incubation Time: 2 hours Result: Inhibited the PGE 2 secretion and inhibited PGE 2 realease.
In Vivo
CAY10650 (50 μg/5 μL; Inject with topical eye-drop; Chinese hamsters) relieves acanthamoeba keratitis in vivo. . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Chinese hamsters with infected with parasite-laden contact lenses Dosage: 50 μg/5 μL Administration: Inject with topical eye-drop under the contact lens; three times a day for 6 days and topically on days 7 to 20 postinfection Result: Reduced the severity of the keratitis and hasten the onset of resolution. Had little mild inflammation and very few PMNs infiltration in the corneal stroma.
规格
规格或纯度
10mM in DMSO
英文名称
CAY10650
生化机理
CAY10650 是一种强效的细胞膜磷脂酶 A2α （cPLA2α）抑制剂，IC 50 值为 12 nM。CAY10650 可抑制脂滴的形成和 PGE2 的分泌。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CC(C)C(=O)C1=CN(C2=C1C=C(C=C2)C(=O)O)CC(=O)COC3=CC=C(C=C3)OC4=CC=CC=C4
PubChem CID
MeSH Entry Terms
3-isobutanoyl-1-(2-oxo-3-(4-phenoxyphenoxy)propyl)indole-5-carboxylic acid;3-isobutanoyl-1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid;3-isobutanoyl-OPICA
分子量
471.50
技术文档
高级数据
关联靶点（人）
PLA2G4A
Tchem
胞浆磷脂酶A2(Cytosolic phospholipase A2)
(1 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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