计算溶液所需的质量、体积或浓度。
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
C75 is a synthetic fatty-acid synthase ( FASN ) inhibitor; inhibits prostate cancer cells PC3 with an IC 50 of 35 μM C75 is a potent CPT1A activator.
In Vitro
C75 inhibits PC3 cell growht with an IC 50 of 35 μM at 24 h. C75 (10-50 μM) also reduces the growth of LNCaP spheroids in a concentration-dependent manner with an IC 50 of 50 μM. (-)-C75 inhibits FAS activity and has a cytotoxic effect on tumor cell lines, without affecting food consumption. (+)-C75 inhibits CPT1 and its administration produces anorexia, suggesting that central inhibition of CPT1 is essential for the anorectic effect of C75. The differential activity of C75 enantiomers may lead to the development of potential new specific drugs for cancer and obesity. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
C75 blocks fasting-induced c-Fos expression in the arcuate nucleus (Arc), lateral hypothalamic area (LHA), and paraventricular nucleus (PVN) 10–24 h after i.p. injection. Intraperitoneal administration of C75 at 30 mg/kg body weight inhibits food intake of mice by ≥95% within 2 h after i.p. injection. C75-treated DIO mice has a 50% greater weight loss, and a 32.9% increased production of energy because of fatty acid oxidation. C75 treatment of rodent adipocytes and hepatocytes and human breast cancer cells increases fatty acid oxidation and ATP levels by increasing CPT-1 activity, even in the presence of elevated concentrations of malonyl-CoA. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:IC50: 35 μM (PC3 cell)
规格
规格或纯度
Moligand™,10mM in DMSO
英文名称
C75
生化机理
C75 是一种合成的脂肪酸合成酶（FASN）抑制剂；对前列腺癌细胞 PC3 的抑制作用 IC 50 为 35 μM。C75 是一种有效的 CPT1A 激活剂。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CCCCCCCCC1C(C(=C)C(=O)O1)C(=O)O
分子量
254.32
Reaxy-Rn
9925444
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9925444&ln=
技术文档
高级数据
安全和危险性（GHS）
WGK Germany
3
个人防护装备
Eyeshields， Gloves， type N95 (US)， type P1 (EN143) respirator filter
RIDADR
NONHforallmodesoftransport
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）