计算溶液所需的质量、体积或浓度。
COR659
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
避光,干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
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文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
COR659 is a potent and effective GABA B positive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.
In Vitro
COR659 apparently exerts its effects via a composite mechanism, including positive allosteric modulation of the GABA B receptor and an action at the cannabinoid CB1 receptor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
COR659 (0, 2.5, 5 and 10 mg/kg) treatment is completely ineffective on lever-responding (FR10) for regular food pellets in food-deprived Wistar rats . COR659 is able to suppress lever-responding for a sucrose solution in sP rats and a chocolate solution in Wistar rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male sP and Wistar rats . Dosage: 0, 2.5, 5 and 10 mg/kg. Administration: Intraperitoneally (administered 30 min before the start of the self-administration, reinstatement, and locomotor activity sessions.). Result: The magnitude of the reducing effect of the compound on number oflever-responses for alcohol averaged approximately 30, 55, and 70%, in comparison to the vehicle-treated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively. The magnitude of the reducing effect of COR659 on number of lever-responses for alcohol averaged approximately 20, 40, and 80%, in comparison to the vehicletreated rat group, in the rat groups treated with 2.5, 5, and 10 mg/kg COR659, respectively.
规格
规格或纯度
Moligand™, 10mM in DMSO
英文名称
COR659
生化机理
COR659 是一种强效、有效的 GABA B 正性异位调节剂（PAM）。COR659 可抑制大鼠对酒精和巧克力的自我摄取。
储存条件
避光,干燥,-80℃储存
运输条件
特低温运输
作用类型
激活剂
名称和识别符
技术文档
高级数据
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