计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CLZ-8 (Compound 8) is an orally active Mcl-1-PUMA interface inhibitor, with a K i of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells
In Vitro
CLZ-8 (Compound 8) (0-160 μM, 48 h) significantly inhibits PUMA-dependent apoptosis. CLZ-8 (0-1 μM, 2 h) significantly enhance the irradiated cell viability in a dose-dependent manner, provides significant protection for HUVECs, and inhibits overexpressed PUMA. CLZ-8 (0-1 μM, 24 h) attenuates the radiation-induced apoptosis. CLZ-8 (1 μM, 2 h) protects HUVECs from DNA breaks. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis Cell Line: DLD-1 cells or HUVEC cells Concentration: 0-160 μM (DLD-1) or 0.01, 0.1 and 1 μM (HUVECs) Incubation Time: 48 h (DLD-1) or 24 h (HUVECs) Result: Significantly inhibited PUMA-dependent apoptosis with an IC 50 of 38.93 ± 0.91 μM. Attenuated the radiation-induced apoptosis. Western Blot AnalysisCell Line: HUVEC cells Concentration: 0.001, 0.01, 0.1 and 1 μM Incubation Time: 2 h Result: Suppressed induction of PUMA after radiation, significantly decreased the level of p53. Significantly decreased the level of MCL-1 and increased the level of Bcl-XL.
In Vivo
CLZ-8 (0-400 mg/kg; i.g.; once) shows powerful anti-radiation effects in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 6-8 week-old male BALB/c miceDosage: 100, 200 and 400 mg/kg Administration: Intragastric administration, once, 30 min prior to irradiation Result: Increased the survival rate of irradiated mice.
IC50& Target:Mcl-1 0.3 μM (Ki) PUMA
规格
规格或纯度
10mM in DMSO
英文名称
CLZ-8
生化机理
CLZ-8（化合物 8）是一种口服活性 Mcl-1-PUMA 界面抑制剂，其 K i 为 0.3 μM。CLZ-8 具有双重活性，既能减少 PUMA 依赖性凋亡，又能使 Mcl-1 介导的癌细胞抗凋亡失活。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
分子类型
小分子
Isomeric SMILES
C1CN(CCN1CCO)C2=NC(=O)/C(=C/C3=CC=C(C=C3)C4=CC=CC=C4)/S2
PubChem CID
分子量
393.50
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）