计算溶液所需的质量、体积或浓度。
CP-609754
有货
为什么选择此级别
Moligand™ 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC 50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 ng/mL.
In Vitro
CP-609754 (CP-609,754) is a reversible inhibitor of farnesyltransferase with a slow on/off rate. CP-609,754 inhibits farnesylation (IC 50 =1.72 ng/mL) of mutant H-Ras in 3T3 H-ras (61L)-transfected cell lines with SDS-PAGE analysis of [ 35 S]methionine-labeled material. CP-609754 is competitive for the prenyl acceptor (H-Ras protein) and noncompetitive for the prenyl donor farnesyl PPI. CP-609754 interacts with the farnesyltransferase-farnesyl PPI complex and competes for the binding of the Ras protein. CP-609754 selectively inhibits farnesylation of both H- and K-Ras proteins in 3T3 transfectants. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CP-609754 (CP-609,754) has antitumor activity against 3T3 H-ras (61L) tumors in vivo . With twice daily oral dosing of CP-609754, tumor regression is achieved with a dose of 100 mg/kg; the ED 50 for tumor growth inhibition is 28 mg/kg . With continuous i.p. infusion of CP-609754, tumor growth is inhibited by >50%, and tumor farnesyltransferase activity inhibited by >30% in mice in which the plasma concentration of CP-609754 is maintained above 118 ng/mL . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
规格
规格或纯度
Moligand™,10mM in DMSO
英文名称
CP-609754
生化机理
CP-609754 (LNK-754) 是一种强效、可逆的法尼基转移酶抑制剂，具有潜在的抗癌活性。抑制重组人 H-Ras 法尼基化的 IC 50 为 0.57 纳克/毫升，重组 K-Ras 为 46 纳克/毫升。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
CN1C=NC=C1[C@@](C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC=CC(=C5)C#C)C)O
关联CAS
PubChem CID
MeSH Entry Terms
CP 609,754;CP 609754;CP-609,754;CP-609754
分子量
479.96
技术文档
高级数据
安全和危险性（GHS）
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 保留所有权利。
危险品化学品经营许可证（带存储）