计算溶液所需的质量、体积或浓度。
概述
CRT0066854 is a potent and selective atypical PKC isoenzymes inhibitor. CRT0066854 is against full-length (FL) PKCι , PKCζ , and ROCK-II kinases with IC 50 values of 132 nM, 639 nM, and 620 nM, respectively
In Vitro
CRT0066854 displaces a crucial Asn-Phe-Asp motif that is part of the adenosine-binding pocket and engages an acidic patch used by arginine-rich PKC substrates. CRT0066854 (0.2-1.2 μM; 6 days) is able to restore polarized morphogenesis in the dysplastic H-Ras spheroids, and the maximal proportion of spheroids with PSALs is at the lower dose of 1.2 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:PKCζ 639 nM (IC 50 ) ROCK2 620 nM (IC 50 )
规格
规格或纯度
10mM in DMSO
英文名称
CRT0066854
生化机理
CRT0066854 是一种强效、选择性非典型 PKC 同工酶抑制剂。CRT0066854 对全长 (FL) PKCι 、PKCζ 和 ROCK-II 激酶的 IC 50 值分别为 132 nM、639 nM 和 620 nM。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
C1CCC2=C(C1)C3=C(N=C(N=C3S2)C4=CC=NC=C4)NC[C@H](CC5=CC=CC=C5)N
PubChem CID
MeSH Entry Terms
3-phenyl-N(1)-(2-pyridin-4-yl-5,6,7,8-tetrahydrobenzo(4,5)thieno(2,3-d)pyrimidin-4-yl)-propane-1,2-diamine;CRT0066854
分子量
415.55
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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