双氢青蒿素

诱导细胞周期停滞并抑制癌细胞中的细胞迁移

14篇引用文献

Moligand™

≥98%

CAS编号: 71939-50-9
分子式: C₁₅H₂₄O₅
分子量: 284.35
MDL号: MFCD00274495
PubChem编号: 3000518
PubChem SID: 504762275

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货号 (SKU)	包装规格	是否现货
D140839-1g	1g	现货
D140839-5g	5g	现货
D140839-25g	25g	现货
D140839-100g	100g	现货

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基本描述

别名	双氢青蒿素
英文别名	β-Dihydroartemisinin \| (3R,5aS,6R,8aS,9R,12R,12aR)-Decahydro-10-hydroxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin \| Alaxin \| Cotecxin \| Cotexin \| DHQHS 2 \| Dihydroartemisinine \| Dihydroqinghaosu.
规格或纯度	Moligand™, ≥98%
英文名称	Dihydroartemisinin
生化机理	诱导细胞周期停滞并抑制癌细胞中的细胞迁移。通过运铁蛋白受体1消耗细胞铁。抗疟和抗肿瘤剂。口服具有活性，在体内和体外具有活性。
应用	抗疟药；抗银屑病；抗炎剂。
储存温度	2-8°C储存,充氩
运输条件	冰袋运输
备注	如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	无臭，味苦。在氯仿中易溶，在丙酮中溶解，在甲醇或乙醇中略溶，在水中几乎不溶。抗疟药；抗银屑病；抗炎剂。 Dihydro Artemisinin is an active antimalarial metabolite. Dihydro Artemisinin is also the main metabolite of Artemisinin, Arteether, Artemether, Artesunate. An active antimalarial metabolite

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名称和识别符

PubChem SID	504762275
分子类型	小分子
IUPAC Name	(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol
INCHI	InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
InChi Key	BJDCWCLMFKKGEE-ISOSDAIHSA-N
Canonical SMILES	CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)O)C
Isomeric SMILES	C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C
RTECS	KD4165550
关联CAS	81496-82-4
PubChem CID	3000518
分子量	284.35
Reaxy-Rn	5813803

化学和物理性质

溶解性	Soluble in DMSO (57 mg/ml) at 25 °C, ethanol (14 mg/ml) at 25 °C, and water (<1 mg/ml) at 25 °C.
密度	1.24
敏感性	对空气、热敏感
熔点	145-150℃
分子量	284.350 g/mol
XLogP3	2.500
氢键供体数Hydrogen Bond Donor Count	1
氢键受体数Hydrogen Bond Acceptor Count	5
可旋转键计数Rotatable Bond Count	0
精确质量Exact Mass	284.162 Da
单同位素质量Monoisotopic Mass	284.162 Da
拓扑极表面积Topological Polar Surface Area	57.200 Å²
重原子数Heavy Atom Count	20
形式电荷Formal Charge	0
复杂度Complexity	415.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	8
未定义的原子立体中心计数Undefined Atom Stereocenter Count	0
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	1

安全和危险性（GHS）

RTECS	KD4165550
Reaxy-Rn	5813803
Merck Index	817

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找到21个结果

批号(Lot Number)	证书类型	日期	货号
C2517767	分析证书	25-03-19	D140839
C2517768	分析证书	25-03-19	D140839
C2517769	分析证书	25-03-19	D140839
C2517766	分析证书	25-03-18	D140839
C2510109	分析证书	25-03-17	D140839
L2406398	分析证书	24-12-13	D140839
L2406397	分析证书	24-12-13	D140839
L2406370	分析证书	24-12-13	D140839
J2409286	分析证书	24-10-11	D140839
J2409285	分析证书	24-10-11	D140839
J2409283	分析证书	24-10-11	D140839
J2409284	分析证书	24-10-11	D140839
J2318332	分析证书	23-10-25	D140839
J2318333	分析证书	23-10-25	D140839
J2318334	分析证书	23-10-25	D140839
I2206668	分析证书	22-09-13	D140839
I2206667	分析证书	22-09-13	D140839
I2206666	分析证书	22-09-13	D140839
C2204427	分析证书	22-03-11	D140839
C2204452	分析证书	22-03-11	D140839
C2204449	分析证书	22-03-11	D140839

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此产品的引用文献

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1. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu. (2024) Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level. DESALINATION, 572 (117124). [PMID:2501086] [10.1016/j.desal.2023.117124]
2. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng. (2023) Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether. MOLECULES, 28 (21): (7452). [PMID:37959871] [10.3390/molecules28217452]
3. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu. (2023) Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 652 (3): (2005). [PMID:37690308] [10.1016/j.jcis.2023.09.028]
4. Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li. (2023) Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma. Small, (2303073). [PMID:37460404] [10.1002/smll.202303073]
5. Qi Duan, Junxia Wu. (2023) Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway. Open Medicine, 18 (1): [PMID:37415610] [10.1515/med-2023-0698]
6. Jing Yan, Faguang Ma, Yilin Wu. (2023) Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design. Materials Today Nano, 23 (100369). [10.1016/j.mtnano.2023.100369]
7. Jingsong Lu, Jing Yu, Wensheng Xie, Zhenhu Guo, Xiaohan Gao, Ying Li, Ziqing Zhang, Zeping Jin, Abdul Fahad, Shenglei Che, Lingyun Zhao, Yen Wei. (2023) Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy. ACS Applied Bio Materials, 6 (6): (2303–2313). [PMID:37190932] [10.1021/acsabm.3c00169]
8. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo. (2023) Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis. Frontiers in Molecular Biosciences, 10 [PMID:37065442] [10.3389/fmolb.2023.1156062]
9. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu. (2023) Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport. CHEMICAL ENGINEERING JOURNAL, 462 (142277). [10.1016/j.cej.2023.142277]
10. Wang Huai-Song, Xia Xingya, Wang Yingming, Lyu Weiping, Sang Mangmang, Gu Congcong, Liu Wenyuan, Zheng Feng. (2021) Anti-cancer adjuvant drug screening via epithelial-mesenchymal transition-related aptamer probe. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (28): (6951-6962). [PMID:34676432] [10.1007/s00216-021-03669-x]
11. Longkai Yang, Qiu Xiong, Yanbo Li, Peng Gao, Ben Xu, Hong Lin, Xin Li, Tsutomu Miyasaka. (2021) Artemisinin-passivated mixed-cation perovskite films for durable flexible perovskite solar cells with over 21% efficiency. Journal of Materials Chemistry A, 9 (3): (1574-1582). [10.1039/D0TA10717D]
12. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu. (2020) Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design. COMPOSITES PART B-ENGINEERING, 198 (108123). [10.1016/j.compositesb.2020.108123]
13. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na. (2018) Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-14). [PMID:30477536] [10.1186/s13046-018-0960-7]
14. Shoubing Wang, Ziran Xu. (2016) Effects of Dihydroartemisinin and Artemether on the Growth, Chlorophyll Fluorescence, and Extracellular Alkaline Phosphatase Activity of the Cyanobacterium Microcystis aeruginosa. PLoS One, 11 (10): (e0164842). [PMID:27755566] [10.1371/journal.pone.0164842]

参考文献

1. Sanford M, McCormack PL. (2015) All chapters. Guidelines for the Treatment of Malaria, 71 (13): (1755-70). [PMID:26020088] [10.1021/op500134e]
2. Bang S et al.. (2021) Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice.. Nat Commun, 12 (1704). [PMID:33731716]
3. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu. (2024) Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level. DESALINATION, 572 (117124). [PMID:2501086] [10.1016/j.desal.2023.117124]
4. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng. (2023) Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether. MOLECULES, 28 (21): (7452). [PMID:37959871] [10.3390/molecules28217452]
5. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu. (2023) Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 652 (3): (2005). [PMID:37690308] [10.1016/j.jcis.2023.09.028]
6. Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li. (2023) Drug Repurposing-Based Brain-Targeting Self-Assembly Nanoplatform Using Enhanced Ferroptosis against Glioblastoma. Small, (2303073). [PMID:37460404] [10.1002/smll.202303073]
7. Qi Duan, Junxia Wu. (2023) Dihydroartemisinin ameliorates cerebral I/R injury in rats via regulating VWF and autophagy-mediated SIRT1/FOXO1 pathway. Open Medicine, 18 (1): [PMID:37415610] [10.1515/med-2023-0698]
8. Jing Yan, Faguang Ma, Yilin Wu. (2023) Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design. Materials Today Nano, 23 (100369). [10.1016/j.mtnano.2023.100369]
9. Jingsong Lu, Jing Yu, Wensheng Xie, Zhenhu Guo, Xiaohan Gao, Ying Li, Ziqing Zhang, Zeping Jin, Abdul Fahad, Shenglei Che, Lingyun Zhao, Yen Wei. (2023) Acidity-Triggered Charge-Convertible Conjugated Polymer for Dihydroartemisinin Delivery and Tumor-Specific Chemo-Photothermal Therapy. ACS Applied Bio Materials, 6 (6): (2303–2313). [PMID:37190932] [10.1021/acsabm.3c00169]
10. Shi Hanqiang, Xiong Lie, Yan Guang, Du Shuqin, Liu Jie, Shi Yanbo. (2023) Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis. Frontiers in Molecular Biosciences, 10 [PMID:37065442] [10.3389/fmolb.2023.1156062]
11. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu. (2023) Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport. CHEMICAL ENGINEERING JOURNAL, 462 (142277). [10.1016/j.cej.2023.142277]
12. Wang Huai-Song, Xia Xingya, Wang Yingming, Lyu Weiping, Sang Mangmang, Gu Congcong, Liu Wenyuan, Zheng Feng. (2021) Anti-cancer adjuvant drug screening via epithelial-mesenchymal transition-related aptamer probe. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (28): (6951-6962). [PMID:34676432] [10.1007/s00216-021-03669-x]
13. Longkai Yang, Qiu Xiong, Yanbo Li, Peng Gao, Ben Xu, Hong Lin, Xin Li, Tsutomu Miyasaka. (2021) Artemisinin-passivated mixed-cation perovskite films for durable flexible perovskite solar cells with over 21% efficiency. Journal of Materials Chemistry A, 9 (3): (1574-1582). [10.1039/D0TA10717D]
14. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu. (2020) Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design. COMPOSITES PART B-ENGINEERING, 198 (108123). [10.1016/j.compositesb.2020.108123]
15. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na. (2018) Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 37 (1): (1-14). [PMID:30477536] [10.1186/s13046-018-0960-7]
16. Shoubing Wang, Ziran Xu. (2016) Effects of Dihydroartemisinin and Artemether on the Growth, Chlorophyll Fluorescence, and Extracellular Alkaline Phosphatase Activity of the Cyanobacterium Microcystis aeruginosa. PLoS One, 11 (10): (e0164842). [PMID:27755566] [10.1371/journal.pone.0164842]

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双氢青蒿素

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名称和识别符

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