DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC 50 value of261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a K i app of 32 nM. DHODH-IN-3 has the potential for malaria treatment.