DW18134 is an inhibitor for interleukin receptor-associated kinase 4 ( IRAK 4 ) with an IC 50 of 11.2 nM. DW18134 inhibits phosphorylation of IRAK4 and IKK , downregulates the secretion of TNF-α and IL-6. DW18134 attenuates the Lipopolysaccharides -induced peritonitis and DSS-induced colitis in mouse models, and protects the intestinal barrier function.