二胺氧化酶 (Diamine Oxidase，简称DAO) 是一种广泛存在于动物、植物和微生物中的酶。在组胺和多种多胺代谢中起作用，其活性与粘膜细胞的核酸和蛋 白合成密切相关，能够反映肠道机械屏障的完整性和受损伤程度。(组胺是一 种常见的过敏原，摄入过量会导致过敏反应、炎症和肠道不适。)
植物源二胺氧化酶通常含有铜离子呈现独特的粉红色。它广泛存在于多 种植物组织中，例如豆类（ 如豌豆、扁豆 ）、十字花科蔬菜（如西兰花、羽 衣甘蓝）等植物中。这些植物不仅提供膳食纤维和营养，还自带天然“解 毒剂”，帮助平衡体内组胺，缓解过敏和炎症。
产品优势
天然来源： 无需依赖动物提取，素食者友好， 适合纯素饮食人群。
稳定性强： 植物源二胺氧化酶在宽泛的pH环境中保持活性， 适应肠道复杂环境。
协同营养：植物中的维生素C、锌等成分， 本身就是二胺氧化酶的辅因子， 双重助力肠道健康。
供货稳定： 规模化生产，供货稳定。
产品功效
降解组胺：二胺氧化酶能够有效地降解体内的组胺，从而减少由于组 胺积聚引起的不适和过敏反应。
改善食物不耐受：增加二胺氧化酶的活性可帮助缓解与食物不耐受相关的症 状，如腹痛、腹泻等。
抗炎作用： 二胺氧化酶被认为具有抗炎特性，可通过调节组胺水平来 减轻炎症反应。
促进伤口愈合： 研究表明，二胺氧化酶在伤口愈合过程中发挥一定的作用 ，通过调节细胞增殖和迁移。
产品应用
营养领域
1. 肠内营养支持与肠道屏障保护 通过补充植物源二胺氧化酶，可以有效增强肠道屏障功能，减少腹胀、腹泻等胃肠道并发症。
2. 组胺不耐受的膳食补充 针对组胺不耐受患者（如慢性荨麻疹、食物过敏），口服DAO补充剂可帮助分解食物中的组胺，缓解头痛、皮疹、 消化不适等症状。
医药领域
1. 治疗组胺相关疾病 重组DAO疗法用于治疗慢性荨麻疹、过敏性休克、先兆子痫等相关疾病。
2. 抗炎与器官保护 二胺氧化酶通过降解组胺，可能减轻肠源性内毒素移位引发的全身炎症反应（SIRS）和多器官功能障碍（MODS）。
Diamine Oxidase (DAO) is an enzyme that is widely present in animals, plants and microorganisms. Playing a role in histamine and a variety of polyamine metabolism, its activity is closely related to the synthesis of nucleic acid and proteins in mucosal cells, and can reflect the integrity and degree of damage of the intestinal mechanical barrier. (Histamine is a common allergen, and excessive intake can lead to allergic reactions, inflammation and intestinal discomfort.)
Plant-derived diamine oxidase (DAO) often contains copper ions, giving it a distinctive pink color. It's found in a wide variety of plant tissues, including legumes (such as peas and lentils) and cruciferous vegetables (such as broccoli and kale). These plants not only provide dietary fiber and nutrients but also act as natural detoxifiers, helping to balance histamine in the body and alleviate allergies and inflammation.
Product Advantages
Natural Source: No need to rely on animal extraction, vegetarian-friendly, suitable for vegan-eating people.
High Stability: Plant-derived diamine oxidase remains active across a wide pH range, adapting to the complex environment of the gut.
Synergistic Nutrition: The vitamin C and zinc found in plants are co-factors of diamine oxidase, providing dual support for gut health.
Stable Supply: Large-scale production, stable supply.
Product Efficacy
Degradation of Histamine: Diamine oxidase can effectively degrade histamine in the body, thus reducing discomfort and allergic reactions caused by histamine accumulation.
Improve Food Intolerance: Increasing the activity of diamine oxidase may help alleviate symptoms related to food intolerances, such as abdominal pain and diarrhea.
Anti-inflammatory Effects: Diamine oxidase is believed to possess anti-inflammatory properties and can reduce inflammatory responses by regulating histamine levels.
Promotion of Wound Healing: Studies indicate that diamine oxidase plays a role in the wound healing process by regulating cell proliferation and migration.
Product Applications
Nutritional Field
1. Enteral nutrition support and intestinal barrier protection By supplementing plant-derived diamine oxidase, it can effectively enhance the function of the intestinal barrier and reduce gastrointestinal complications such as abdominal distension and diarrhea.
2. Dietary supplements for histamine intolerance For patients with histamine intolerance (such as chronic urticaria, food allergy), oral DAO supplements can help break down histamine in food and relieve symptoms such as headache, rash, and digestive discomfort.
Pharmaceutical Field
1. Treatment of histamine-related diseases Recombinant DAO therapy is used to treat chronic urticaria, anaphylactic shock, preeclampsia, and related diseases.
2. Anti-inflammatory and organ protection Diamine oxidase may reduce systemic inflammatory responses (SIRS) and multi-organ dysfunction (MODS) caused by intestinal endotoxin shifts.
ZJ26F0333631
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