香叶木素

CYP1 Selective Inhibitors

有货

关闭

货号 (SKU)	包装规格	是否现货	价格	数量
D407875-1ml	1ml	现货

查看相关系列

Compound libraries (12332)

基本描述

英文别名	Luteolin 4-methyl ether \| 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-
规格或纯度	10mM in DMSO
英文名称	Diosmetin
生化机理	Diosmetin （叶黄素 4-甲醚）是一种生物类黄酮，存在于留兰香、牛至和许多其他植物中。
储存温度	-80℃储存
运输条件	超低温冰袋运输
产品介绍	药理作用：抗氧化、抗诱变和抗变异性作用，抑制人CYP1A酶活力。 Information Diosmetin (Luteolin 4-methyl ether) is a bioflavonoid found in spearmint, oregano, and many other plants. In vitro Diosmetin inhibits 3H-dopamine uptake in neuroblastoma cells, as well as in small-cell lung carcinoma cells, which is be responsible for the increased vascular tone observed in vivo after treatment with Diosmetin. Moreover, Diosmetin also removes iron from iron-loaded hepatocytes revealed a good relationship between this iron-chelating ability and the cytoprotective effect. Other studies proves that Diosmetin is a cytochrome P450 inhibitor, thus inhibiting carcinogen activation and and causing pharmacokinetic interactions with co-administered drugs metabolized. In vivo Cell Data cell lines：Human MT-4 cells Concentrations： Incubation Time： Powder Purity:≥99%

CYP1B1 Tchem 细胞色素 P450 1B1(Cytochrome P450 1B1) (3 活性数据)

点击查看靶蛋白信息： CYP1B1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

CYP1A1 Tchem 细胞色素 P450 1A1(Cytochrome P450 1A1) (2 活性数据)

点击查看靶蛋白信息： CYP1A1

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

分子类型	小分子
Canonical SMILES	COC1=CC=C(C=C1O)C2=CC(=O)C3=C(O)C=C(O)C=C3O2
分子量	300.26
Reaxy-Rn	294492
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=294492&ln=

溶解性	Solubility (25°C) In vitro Water: 29 mg/mL (201.45 mM); DMSO: Insoluble; Ethanol: Insoluble;
DMSO(mg / mL) Max Solubility	60
DMSO(mM) Max Solubility	199.83
Water(mg / mL) Max Solubility	<1

Reaxy-Rn	294492
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=294492&ln=

Concentration	9-11（mmol/L）
Proton NMR spectrum	Conforms to Structure

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

1. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
2. Li-Feng Li, Meng-Di Wang, Chen-Yang Zhang, Meng-Yao Jin, Hua-Lei Chen, Huan Luo, Tian-Yu Hou, Zhi-Jun Zhang, He Li. (2025) Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models. FOOD RESEARCH INTERNATIONAL, 207 (116068). [PMID:40086959] [10.1016/j.foodres.2025.116068]

1. Shuzhen Yang, Jie Zhou, Dongmei Li, Chunyu Shang, Litao Peng, Siyi Pan. (2017) The structure-antifungal activity relationship of 5,7-dihydroxyflavonoids against Penicillium italicum. FOOD CHEMISTRY, 224 (26). [PMID:28159264] [10.1016/j.foodchem.2016.12.001]
2. Li-Feng Li, Meng-Di Wang, Chen-Yang Zhang, Meng-Yao Jin, Hua-Lei Chen, Huan Luo, Tian-Yu Hou, Zhi-Jun Zhang, He Li. (2025) Influence of hydroxyl substitution on the inhibition of flavonoids in advanced glycation end-products formation in glucose-lysine-arginine Maillard reaction models. FOOD RESEARCH INTERNATIONAL, 207 (116068). [PMID:40086959] [10.1016/j.foodres.2025.116068]