溴化十烃季胺, 肌肉型烟碱乙酰胆碱受体部分激动剂

nAChR 选择性抑制剂 | 激动剂 | 拮抗剂 | 调节剂

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货号 (SKU)	包装规格	是否现货	价格	数量
D408329-1ml	1ml	现货

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Compound libraries (12332)

基本描述

英文别名	1,10-Decanediaminium, N1,N1,N1,N10,N10,N10-hexamethyl-, bromide (1:2)
规格或纯度	10mM in DMSO
英文名称	Decamethonium Bromide
生化机理	癸甲溴铵是一种烟碱 AChR 部分激动剂和神经肌肉阻断剂。
储存温度	-80℃储存
运输条件	超低温冰袋运输
作用类型	部分激动剂
作用机制	肌肉型烟碱乙酰胆碱受体部分激动剂
产品介绍	Decamethonium bromide has been used to induce paralysis in duck embryo. Information Decamethonium Bromide is a nicotinicAChRpartial agonist andneuromuscularblocking agent. In vitro Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent, and is used in anesthesia to induce paralysis. Decamethonium, which has a short action time, is similar to acetylcholine and acts as a partial agonist of the nicotinic acetylcholine receptor. In the motor endplate, it causes depolarization, preventing further effects to the normal release of acetylcholine from the presynaptic terminal, and therefore preventing the neural stimulus from affecting the muscle. In the process of binding, decamethonium actually activates (depolarizes) the motor endplate, but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release. In vivo Cell Data cell lines： Concentrations： Incubation Time： Powder Purity:≥100%

ALogP	-3.707
Rotatable Bond	11

ACHE Tclin 乙酰胆碱酯酶(Acetylcholinesterase) (1 活性数据)

点击查看靶蛋白信息： ACHE

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

分子类型	小分子
Canonical SMILES	[Br-].[Br-].C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C
分子量	418.29
Reaxy-Rn	3728288
Reaxys-RN link address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3728288&ln=

溶解性	Solubility (25°C) In vitro DMSO: 59 mg/mL (198.82 mM); Ethanol: 2 mg/mL (6.73 mM); Water: Insoluble;
DMSO(mg / mL) Max Solubility	34
DMSO(mM) Max Solubility	81.28
Water(mg / mL) Max Solubility	84
Water(mM) Max Solubility	200.82