| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D408521-1ml |
1ml |
现货  |
|
| 英文别名 | SR33589 | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide,hydrochloride (1:1) |
|---|---|
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Dronedarone HCl |
| 生化机理 | 盐酸决奈达隆（SR33589）是一种针对钾通道、钠通道和钙通道的多通道阻滞剂，是治疗心房颤动（房颤）的抗心律失常药物。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 封闭剂 |
| 作用机制 | 电压门 L 型钙通道阻滞剂 |
| 产品介绍 |
Information Dronedarone HCl Dronedarone HCl (SR33589) is a multichannel blocker targeting potassium channel , sodium channel and calcium channel , used as an antiarrhythmic drug for treatment of atrial fibrillation (AF). Dronedarone reduces the incidence of early and delayed after depolarizations evoked by 1 mM Dofetilide and 0.2 mM Strophantidine in Purkinje fibres. Dronedarone (10 mM) markedly reduces the L-type calcium current (76.5%) and the rapid component of the delayed rectifier potassium current (97%) in ventricular myocytes. Dronedarone inhibits the activity of I(K(ACh)) channels recorded from cell-attached patches by reducing the channel open probability (from 0.56 to 0.11) without modification of the single-channel conductance in single cells isolated from sinoatrial node (SAN) tissue of rabbit hearts. Dronedarone exhibits a state-dependent inhibition of the fast Na(+) channel current with an IC50 of 0.7 μM in guinea pig ventricular myocytes, when the holding potential (V (hold)) is -80 mV. Dronedarone blocks Ca(2+) currents elicited by rectangular pulses at V (hold)\u2009=\u2009-40 mV with IC50 value of 0.4 μM, whereas at V (hold)\u2009=\u2009-80 mV, Dronedarone (10 μM) blocks only 20\u2009% of the current. In vivo Dronedarone increases action potential duration in normal hearts of rats. Dronedarone reduces the late sustained K(+) current, I(K) (or Isus) by 69%. Dronedarone induces only a tonic block of I(K). Dronedarone induces a weak increase in the fast transient outward current, I(to), in rats after myocardial infarction. cell lines：Human breast cancer cells MDA-MB-468 Concentrations： Incubation Time： Powder Purity:≥99% |
| ALogP | 7.397 |
|---|---|
| hba_count | 5 |
| HBD Count | 1 |
| Rotatable Bond | 18 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | Cl.CCCCN(CCCC)CCCOC1=CC=C(C=C1)C(=O)C2=C(CCCC)OC3=CC=C(N[S](C)(=O)=O)C=C23 |
| 分子量 | 593.22 |
| Reaxy-Rn | 8380427 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8380427&ln= |
| DMSO(mg / mL) Max Solubility | 80 |
|---|---|
| DMSO(mM) Max Solubility | 134.86 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 8380427 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=8380427&ln= |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
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