| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D408674-1ml |
1ml |
现货  |
|
| 英文别名 | BAY-1841788 | N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Darolutamide (ODM-201) |
| 生化机理 | Darolutamide（ODM-201，BAY-1841788）是一种新型雄激素受体（AR）拮抗剂，可阻断 AR 核转位，Ki值为 11 nM。第 3 阶段 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 拮抗剂 |
| 作用机制 | 雄激素受体拮抗剂 |
| 产品介绍 |
Information Darolutamide (ODM-201) Darolutamide (ODM-201, BAY-1841788) is a novel androgen receptor (AR) antagonist that blocks AR nuclear translocation with K i of 11 nM. Phase 3. In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. In vivo In mice bearing VCaP xenografts, ODM-201 (50\u2009mg/kg, p.o.) significantly inhibits castration-resistant prostate tumor growth. cell lines： Concentrations：~10 μM Incubation Time：4 days Powder Purity:≥99% |
| ALogP | 3.034 |
|---|---|
| hba_count | 3 |
| HBD Count | 3 |
| Rotatable Bond | 6 |
| 分子类型 | 小分子 |
|---|---|
| Canonical SMILES | CC(O)C1=CC(=N[NH]1)C(=O)NC(C)C[N]2C=CC(=N2)C3=CC(=C(C=C3)C#N)Cl |
| 分子量 | 398.85 |
| Reaxy-Rn | 23068895 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23068895&ln= |
| DMSO(mg / mL) Max Solubility | 80 |
|---|---|
| DMSO(mM) Max Solubility | 200.58 |
| Water(mg / mL) Max Solubility | <1 |
| Reaxy-Rn | 23068895 |
|---|---|
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=23068895&ln= |
| Concentration | 9-11（mmol/L） |
|---|---|
| Proton NMR spectrum | Conforms to Structure |
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