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概述
Dapoxetine HCl 是一种短效的，新型选择性5-羟色胺再摄取抑制剂。
本品仅供科研使用。
达泊西汀（(+)-(S)-N,N-二甲基-(α)-[2(1萘氧基)乙基]-苯甲胺盐酸盐）的结构类似于氟西汀。
Information
Dapoxetine HCl Dapoxetine HCl (LY-210448) is a short-acting novel selective serotonin reuptake inhibitor, used for the treatment of premature ejaculation.
In vitro
Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3 currents. Dapoxetine decreases the peak amplitude of Kv1.5 currents and accelerates the decay rate of current inactivation in a concentration-dependent manner with an IC50 of 11.6 μM. Dapoxetine decreases the tail current amplitude and slows the deactivation process of Kv1.5, which results in a tail crossover phenomenon. Dapoxetine produces a use-dependent block of Kv1.5 at frequencies of 1 and 2 Hz and slowed the time course for recovery of inactivation. Dapoxetine also appears to be a useful adjunct to morphine, lowering the threshold for analgesia, although Dapoxetine itself has negligible analgesic activity. Dapoxetine is the D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
规格
英文别名
LY-210448
规格或纯度
10mM in DMSO
英文名称
Dapoxetine HCl
生化机理
盐酸达泊西汀（LY-210448）是一种短效新型选择性血清素再摄取抑制剂，用于治疗早泄。
储存条件
-80℃储存
运输条件
特低温运输
名称和识别符
EC号
640-411-8
分子类型
小分子
Isomeric SMILES
CN(C)[C@@H](CCOC1=CC=CC2=CC=CC=C21)C3=CC=CC=C3.Cl
分子量
341.87
Reaxy-Rn
32311059
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=32311059&ln=
高级数据
化学和物理性质
比旋光度
125° (C=1,MeOH)
熔点
181 °C
安全和危险性（GHS）
信号词
警告
危险声明
H302: 吞食有害
H319: 引起严重眼睛刺激
H413: 可能对水生生物造成长期持续有害影响
WGK Germany
3
Merck Index
2821
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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