| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| D420883-1ml |
1ml |
现货  |
|
| 别名 | 盐酸多奈哌齐 |
|---|---|
| 英文别名 | DONEPEZIL HYDROCHLORIDE [JAN] | DONEPEZIL HYDROCHLORIDE [MI] | s2462 | (2RS)-2-((1-Benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one monohydrochloride | CCG-101043 | Tox21_112534_1 | DTXCID8026698 | E 2020 | EN300-269733 | FT-0602354 |
| 规格或纯度 | 10mM in Water |
| 英文名称 | Donepezil HCl |
| 生化机理 | 盐酸多奈哌齐是一种非竞争性乙酰胆碱酯酶抑制剂（IC50 = 11.6 nM）。众所周知，盐酸多奈哌齐是研究阿尔茨海默病的有效工具。研究表明，盐酸多奈哌齐可保护大脑免受二异丙基氟磷酸盐的影响。研究表明，盐酸多奈哌齐可选择性地抑制乙酰胆碱酯酶，而对丁酰胆碱酯酶的影响很小。其他研究表明，盐酸多奈哌齐可增加细胞外乙酰胆碱的浓度。对乙酰胆碱酯酶的选择性大于丁酰胆碱酯酶的 1250 倍。具有中枢活性。具有体外和体内神经保护活性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | 乙酰胆碱酯酶抑制剂 |
| 产品介绍 |
Donepezil HCl 是一种特异性的，有效的AChE抑制剂，作用于bAChE和hAChE，IC50分别为8.12 nM和11.6 nM。 Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 活性类型 | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride |
| INCHI | InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H |
| InChi Key | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
| Canonical SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl |
| Isomeric SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl |
| WGK Germany | 1 |
| RTECS | NK8927885 |
| 关联CAS | 110119-84-1 |
| 分子量 | 415.96 |
| Reaxy-Rn | 7062905 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7062905&ln= |
| 敏感性 | 对湿度敏感 |
|---|---|
| 熔点 | 220-222°C |
| 分子量 | 416.000 g/mol |
| XLogP3 | |
| 氢键供体数Hydrogen Bond Donor Count | 1 |
| 氢键受体数Hydrogen Bond Acceptor Count | 4 |
| 可旋转键计数Rotatable Bond Count | 6 |
| 精确质量Exact Mass | 415.191 Da |
| 单同位素质量Monoisotopic Mass | 415.191 Da |
| 拓扑极表面积Topological Polar Surface Area | 38.800 Ų |
| 重原子数Heavy Atom Count | 29 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 510.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 2 |
| 象形图 | GHS06, GHS07 |
|---|---|
| 信号词 | Danger |
| 危险声明 |
H319: 引起严重眼睛刺激 H301: 吞咽会中毒 |
| 预防措施声明 |
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 |
| WGK Germany | 1 |
| RTECS | NK8927885 |
| Reaxy-Rn | 7062905 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7062905&ln= |
| Merck Index | 3419 |
| Concentration(Compounding value) | 9-11（mmol/L） |
|---|---|
| Record the entire process by video | Conform |
| 1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12): (116013). [PMID:38052155] [10.1016/j.ejmech.2023.116013] |
| 2. Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu. (2023) Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, (15): (115765). [PMID:37844366] [10.1016/j.jpba.2023.115765] |
| 3. Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han. (2022) Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY, 292 (115194). [PMID:35304276] [10.1016/j.jep.2022.115194] |
| 4. Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis. Frontiers in Aging Neuroscience, 13 (942). [PMID:35126093] [10.3389/fnagi.2021.809433] |
| 5. Li Ying-Qi, Chen Yi, Jiang Si-Qi, Shi Yuan-Yuan, Jiang Xiao-Li, Wu Shan-Shan, Zhou Ping, Wang Hui-Ying, Li Ping, Li Fei. (2021) An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease. Frontiers in Cell and Developmental Biology, 9 (1907). [PMID:34350171] [10.3389/fcell.2021.652310] |
| 6. Liping Zhao, Ge Yang, Linsen Li, Chao Zhu, Yao Ma, Feng Qu. (2020) Aptamer-functionalized magnetic nanoparticles conjugated organic framework for immobilization of acetylcholinesterase and its application in inhibitors screening. ANALYTICA CHIMICA ACTA, 1140 (228). [PMID:33218485] [10.1016/j.aca.2020.10.024] |
| 7. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. JOURNAL OF ETHNOPHARMACOLOGY, 254 (112764). [PMID:32173426] [10.1016/j.jep.2020.112764] |
| 8. Min Tao, Li Zhang, Yinlong Guo. (2018) Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 29 (12): (2427–2435). [PMID:30159674] [10.1007/s13361-018-2054-3] |
| 9. Wu M, Ma J, Ji L, Wang M, Han J, Li Z.. (2019) Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 177 (198-211). [PMID:31136894] [10.1016/j.ejmech.2019.05.055] |
| 10. Yue Chen, Hai-Long Wu, Tong Wang, Ru-Qin Yu. (2024) A calibration model transfer method based on quadrilinear model for excitation-emission matrix fluorescence measurements on different fluorescence spectrophotometers. MICROCHEMICAL JOURNAL, 199 (110053). [10.1016/j.microc.2024.110053] |
| 11. Donglin Xiang, Shuyi Qiu, Laping He, Chun Ji, Jiayu Chen, Yuangen Wu, Han Tao. (2024) Purification, characterization of a plant esterase from red kidney bean and its feasibility for pesticide residue analysis in foods. Food Bioscience, 59 (103944). [10.1016/j.fbio.2024.103944] |
| 12. Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou. (2024) Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway. NEUROSCIENCE LETTERS, (137769). [PMID:38616003] [10.1016/j.neulet.2024.137769] |
| 1. Shuanghong Dong, Jucheng Xia, Fang Wang, Lili Yang, Siqi Xing, Jiyu Du, Tingting Zhang, Zeng Li. (2024) Discovery of novel deoxyvasicinone derivatives with benzenesulfonamide substituents as multifunctional agents against Alzheimer's disease. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 264 (12): (116013). [PMID:38052155] [10.1016/j.ejmech.2023.116013] |
| 2. Siyue Li, Yuanfang Sun, Yutong Gao, Xinying Yu, Chun Zhao, Xiuping Song, Fei Han, Jia Yu. (2023) Spectrum-effect relationship analysis based on HPLC-FT-ICR-MS and multivariate statistical analysis to reveal the pharmacodynamic substances of Ling-Gui-Zhu-Gan decoction on Alzheimer's disease. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, (15): (115765). [PMID:37844366] [10.1016/j.jpba.2023.115765] |
| 3. Jing Han, Haotian Zhang, Yu Zhang, Zan Zhang, Maomao Yu, Sijie Wang, Fei Han. (2022) Lingguizhugan decoction protects PC12 cells against Aβ25-35-induced oxidative stress and neuroinflammation by modulating NF-κB/MAPK signaling pathways. JOURNAL OF ETHNOPHARMACOLOGY, 292 (115194). [PMID:35304276] [10.1016/j.jep.2022.115194] |
| 4. Cai Yawen, Chai Yuhui, Fu Yu, Wang Yingdi, Zhang Yiming, Zhang Xue, Zhu Lingpeng, Miao Mingxing, Yan Tianhua. (2022) Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis. Frontiers in Aging Neuroscience, 13 (942). [PMID:35126093] [10.3389/fnagi.2021.809433] |
| 5. Li Ying-Qi, Chen Yi, Jiang Si-Qi, Shi Yuan-Yuan, Jiang Xiao-Li, Wu Shan-Shan, Zhou Ping, Wang Hui-Ying, Li Ping, Li Fei. (2021) An Inhibitor of NF-κB and an Agonist of AMPK: Network Prediction and Multi-Omics Integration to Derive Signaling Pathways for Acteoside Against Alzheimer’s Disease. Frontiers in Cell and Developmental Biology, 9 (1907). [PMID:34350171] [10.3389/fcell.2021.652310] |
| 6. Liping Zhao, Ge Yang, Linsen Li, Chao Zhu, Yao Ma, Feng Qu. (2020) Aptamer-functionalized magnetic nanoparticles conjugated organic framework for immobilization of acetylcholinesterase and its application in inhibitors screening. ANALYTICA CHIMICA ACTA, 1140 (228). [PMID:33218485] [10.1016/j.aca.2020.10.024] |
| 7. Ying-Qi Li, Yi Chen, Jia-Yi Fang, Si-Qi Jiang, Ping Li, Fei Li. (2020) Integrated network pharmacology and zebrafish model to investigate dual-effects components of Cistanche tubulosa for treating both Osteoporosis and Alzheimer's Disease. JOURNAL OF ETHNOPHARMACOLOGY, 254 (112764). [PMID:32173426] [10.1016/j.jep.2020.112764] |
| 8. Min Tao, Li Zhang, Yinlong Guo. (2018) Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 29 (12): (2427–2435). [PMID:30159674] [10.1007/s13361-018-2054-3] |
| 9. Wu M, Ma J, Ji L, Wang M, Han J, Li Z.. (2019) Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.. Eur J Med Chem, 177 (198-211). [PMID:31136894] [10.1016/j.ejmech.2019.05.055] |
| 10. Yue Chen, Hai-Long Wu, Tong Wang, Ru-Qin Yu. (2024) A calibration model transfer method based on quadrilinear model for excitation-emission matrix fluorescence measurements on different fluorescence spectrophotometers. MICROCHEMICAL JOURNAL, 199 (110053). [10.1016/j.microc.2024.110053] |
| 11. Donglin Xiang, Shuyi Qiu, Laping He, Chun Ji, Jiayu Chen, Yuangen Wu, Han Tao. (2024) Purification, characterization of a plant esterase from red kidney bean and its feasibility for pesticide residue analysis in foods. Food Bioscience, 59 (103944). [10.1016/j.fbio.2024.103944] |
| 12. Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zhou. (2024) Study on the role and mechanism of Tan IIA in Alzheimer’s disease based on CREB-BDNF-TrkB pathway. NEUROSCIENCE LETTERS, (137769). [PMID:38616003] [10.1016/j.neulet.2024.137769] |
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