计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with K i of 6.3 and 4.2 nM, respectively. [ 11 C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging
In Vitro
Designer Receptors Exclusively Activated by Designer Drugs (DREADD) are a chemogenetic approach for remote manipulation of neuronal activity in freely-moving animals. DREADDs comprise mutated G protein-coupled receptors (GPCRs) that do not respond to their endogenous neurotransmitter, but do respond to an otherwise “inert” exogenous substance. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Deschloroclozapine (0.3?mg/kg; intramuscularly) impairs working memory function in male rhesus macaques (aged between 5 and 6 years and weighing 5.5-7.9?kg). ?\nDeschloroclozapine (0.1?mg/kg; i.m) is effective at activating DREADD receptors in vivo and reversibly inducing behavioral effects in monkeys. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:mAChR3 mAChR4
规格
别名
去氯氯氮平
规格或纯度
10mM in DMSO
英文名称
Deschloroclozapine
生化机理
去氯氯氮平是氯氮平的代谢产物，是一种强效毒蕈碱类 DREADDs 激动剂。去氯氯氮平能与 DREADD 受体亚型 hM3Dq 和 hM4Di 结合，K i 分别为 6.3 和 4.2 nM。[11C]-地氯氯氮平被开发为一种新型的 DREADD 受体激动剂。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
名称和识别符
EC号
112-636-7
分子类型
小分子
Isomeric SMILES
CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C42
PubChem CID
分子量
292.4
技术文档
高级数据
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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