计算溶液所需的质量、体积或浓度。
概述
DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM.
IC50& Target:IC50: 84 nM (KDM1A/LSD1)
In Vitro:DDP-38003 inhibits KDM1A with an IC 50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue. MCE has not independently confirmed the accuracy of th
In Vivo:DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is ob
Biological Activity:DDP-38003 trihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A ( KDM1A/LSD1 ) with an IC 50 of 84 nM.
规格
别名
DDP-38003 三盐酸盐
规格或纯度
10mM in DMSO
英文名称
DDP-38003 trihydrochloride
储存条件
充氩,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
分子量
459.84
高级数据
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