DPP9 is a protease of the DPP4 gene family that is used in cancer research to study the regulation of survival and proliferation pathways. DPP9 is used to study cell-extracellular matrix interactions and tissue remodeling.
DPP9 is a protease of the DPP4 gene family that is used in cancer research to study the regulation of survival and proliferation pathways. DPP9 is used to study cell-extracellular matrix interactions and tissue remodeling.
规格
规格或纯度
重组, expressed in Sf9 cells
英文名称
Dipeptidyl Peptidase IX human
生化机理
DPP IX 是二肽基肽酶 S9b 家族的成员,能裂解肽类激素胰高血糖素样肽-1、胰高血糖素样肽-2、神经肽 Y 和肽 YY,与二肽基肽酶 IV 相比,其动力学差异明显。 它通过调节分子信号级联在调节细胞存活和增殖方面发挥作用。 在人肝癌细胞(HepG2 和 Huh7)和人胚胎肾细胞(HEK293T)中过量表达人 DPP9 可显著抑制蛋白激酶 B 的活化 。 DPP9 被认为会影响细胞与细胞外基质的相互作用,并可能参与组织重塑的调控 。