Ebselen derivative 1 (Compound 19) is a glutathione peroxidase (GPx) mimic with oral activity. Ebselen derivative 1 demonstrates significant protective effects against cisplatin -induced hair cell (HC) damage both in vitro and in vivo , effectively reducing oxidative stress, apoptosis , and ferroptosis in hair cells. Ebselen derivative 1 can be utilized in the research of cisplatin -induced hearing loss.