Eudragit RS 100 is a mucoadhesive, nonbiodegradable positively charged polymer,which can be used for research of developing nanoparticles (NPs) for the ophthalmic and oral administration of Ibuprofen and Cyclosporin s , as well as nano- and micro-fibres used as scaffolds. Eudragit RS 100 NPs interacts efficiently with mucin and promotes glutathione (GSH) transmucosal absorption.