E3 Ligase Ligand-linker Conjugate 27 is a conjugate of E3 ligase ligand and linker , consisting of (S,R,S)-AHPC and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 Ligase Ligand-linker Conjugate 27 can be used as a key intermediate for the synthesis of complete PROTAC molecules.