ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a K d value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities.