计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Information
Equol ,a metabolite of soybeans, is an important isoflavone in humans，specifically binds to 5α-DHT, has a modest affinity for recombinant estrogen receptor ERβ. Phase 2.
In vitro
Equol is a metabolite produced from the soy phytoestrogen daidzein by the action of gut microflora. Equol has higher affinity for both ERs (estrogen receptors including ERalpha and ERbeta). Equol exists as the enantiomers R-equol and S-equol. S-equol has a high binding affinity, preferential for ERbeta with a Ki of 16 nM whereas R-equol binds more weakly and with a preference for ERalpha K with a Ki of 50 nM. Equol is superior to all other isoflavones in its antioxidant activity. Equol has antioestrogenic properties. Equol is a 100-fold more potent than daidzein in stimulating an oestrogenic response. Equol is also more effective than daidzein in competing with 3 H-oestradiol for binding to the ER. Equol stimulates the growth of MCF-7 cells in a concentration-dependent manner. Although equol exhibits oestrogenic activity, exposure of MCF-7 cells to equol simultaneously with oestradiol is effective in reducing pS2 mRNA expression. Equol results in the downregulation of ER mRNA expression.
In vivo
Cell Data
cell lines：
Concentrations：0 μM-10 μM
Incubation Time：24 hours
Powder Purity:≥99%
规格
英文别名
2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)-
规格或纯度
10mM in DMSO
英文名称
Equol
生化机理
Equol是大豆的代谢产物，是人体中一种重要的异黄酮，能与5α-DHT特异性结合，对重组雌激素受体ERβ有一定的亲和力。第 2 阶段
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
作用机制
雌激素受体 beta 激动剂
名称和识别符
EC号
208-522-2
分子类型
小分子
Isomeric SMILES
C1[C@H](COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O
关联CAS
分子量
242.27
Reaxy-Rn
87753
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=87753&ln=
技术文档
高级数据
产品属性
| ALogP | 3 |
|---|
化学和物理性质
溶解性
Solubility (25°C) In vitro DMSO: 31 mg/mL (196.0 mM); Water: 31 mg/mL (196.0 mM); Ethanol: Insoluble;
安全和危险性（GHS）
RTECS
DJ2887080
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
技术文档和文章
Isoflavones
目录： 技术文章
此产品的引用文献
溶液计算器
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