| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| E421607-1ml |
1ml |
现货  |
|
| 别名 | GF 120918 | 依克立达 | N-[4-[2-(3,4-二氢-6,7-二甲氧基-2(1H)-异喹啉基)乙基]苯基]-9,10-二氢-5-甲氧基-9-氧代-4-吖啶甲酰胺 | N-[4-[2-(3,4-二氢-6,7-二甲氧基-2 (1H)-异喹啉基)乙基] 苯基]-9,10-二氢-5-甲氧基-9-氧代-4-吖啶甲酰胺 |
|---|---|
| 英文别名 | Elacridar | 143664-11-3 | GF120918 | Elacridar [INN] | GF-120918 | GG918 | N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide | Elacridar (GF120918) | GF 120918 | CHEMBL396298 | N-(4-(2-(6,7-dimethoxy-3,4-dihydrois |
| 规格或纯度 | 10mM in DMSO |
| 英文名称 | Elacridar |
| 生化机理 | 一种典型的 BCRP（ABCG2）和 MDR-1 抑制剂，可抑制 Bcrp1 介导的转运。它能增加细胞毒性抗肿瘤药物的利用率。允许大脑和中枢神经系统吸收更多的抗艾滋病毒药物。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 产品介绍 |
Elacridar(GF120918; GW0918)是P-糖蛋白抑制剂，在体内外实验中常作为工具化合物。 Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | N-[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]-5-methoxy-9-oxo-10H-acridine-4-carboxamide |
| INCHI | InChI=1S/C34H33N3O5/c1-40-28-9-5-7-26-32(28)36-31-25(33(26)38)6-4-8-27(31)34(39)35-24-12-10-21(11-13-24)14-16-37-17-15-22-18-29(41-2)30(42-3)19-23(22)20-37/h4-13,18-19H,14-17,20H2,1-3H3,(H,35,39)(H,36,38) |
| InChi Key | OSFCMRGOZNQUSW-UHFFFAOYSA-N |
| Canonical SMILES | COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC |
| Isomeric SMILES | COC1=CC=CC2=C1NC3=C(C2=O)C=CC=C3C(=O)NC4=CC=C(C=C4)CCN5CCC6=CC(=C(C=C6C5)OC)OC |
| WGK Germany | 3 |
| RTECS | AR7621300 |
| 分子量 | 563.64 |
| Reaxy-Rn | 7324887 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7324887&ln= |
| 敏感性 | 对热敏感 |
|---|---|
| 熔点 | 210 °C |
| 分子量 | 563.600 g/mol |
| XLogP3 | 5.600 |
| 氢键供体数Hydrogen Bond Donor Count | 2 |
| 氢键受体数Hydrogen Bond Acceptor Count | 7 |
| 可旋转键计数Rotatable Bond Count | 8 |
| 精确质量Exact Mass | 563.242 Da |
| 单同位素质量Monoisotopic Mass | 563.242 Da |
| 拓扑极表面积Topological Polar Surface Area | 89.100 Ų |
| 重原子数Heavy Atom Count | 42 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 925.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 0 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| WGK Germany | 3 |
|---|---|
| RTECS | AR7621300 |
| Reaxy-Rn | 7324887 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7324887&ln= |
| concentration | 9.0-11.0（mmol/L） |
|---|---|
| NMR Spectrum 1H | Conforms to Structure |
| 1. Jieyu Zhang, Yan Chen, Wenxiang Fan, Linnan Li, Yueming Ma, Zhengtao Wang, Rong Shi, Li Yang. (2023) Study on herb-herb interaction between active components of Plantago asiatica L. seed and Coptis chinensis Franch. rhizoma based on transporters using UHPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 227 (115234). [PMID:36773541] [10.1016/j.jpba.2023.115234] |
| 2. Qiurui Li, Hua Lin, Yanfen Niu, Yan Liu, Zhenyu Wang, Liudong Song, Lihui Gao, Ling Li. (2020) Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. EUROPEAN JOURNAL OF PHARMACOLOGY, 888 (173490). [PMID:32827538] [10.1016/j.ejphar.2020.173490] |
| 1. Jieyu Zhang, Yan Chen, Wenxiang Fan, Linnan Li, Yueming Ma, Zhengtao Wang, Rong Shi, Li Yang. (2023) Study on herb-herb interaction between active components of Plantago asiatica L. seed and Coptis chinensis Franch. rhizoma based on transporters using UHPLC-MS/MS. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 227 (115234). [PMID:36773541] [10.1016/j.jpba.2023.115234] |
| 2. Qiurui Li, Hua Lin, Yanfen Niu, Yan Liu, Zhenyu Wang, Liudong Song, Lihui Gao, Ling Li. (2020) Mangiferin promotes intestinal elimination of uric acid by modulating intestinal transporters. EUROPEAN JOURNAL OF PHARMACOLOGY, 888 (173490). [PMID:32827538] [10.1016/j.ejphar.2020.173490] |
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