计算溶液所需的质量、体积或浓度。
概述
EW-7195 is a potent and selective ALK5 (TGFβR1) inhibitor with an IC 50 of 4.83 nM. EW-7195 has >300-fold selectivity for ALK5 over p38α . EW-7195 efficiently inhibits TGF-β1-induced Smad signaling, epithelial-to-mesenchymal transition (EMT) and breast tumour metastasis to the lung
In Vitro
EW7195 inhibits the EMT, motility, and invasiveness of breast cancer cells in vitro. EW-7195 efficiently blocks TGF-β1-induced phosphorylation of Smad2 followed by the nuclear translocation of Smad2/3. EW-7195 blocks TGF-β1-induced mesenchymal morphology. EW-7195 inhibits TGF-β-induced transcriptional activation. EW-7195 (0.5-1 µM; 1.5 hours) efficiently inhibits TGF-β1-induced Smad2 phosphorylation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
EW7195 (40 mg/kg; i.p.; three times a week for 3/2.5 weeks) inhibits lung metastasis development in both 4T1 orthotopic xenograft and MMTV/cNeu transgenic mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MMTV/c-Neu mice Dosage: 40 mg/kg Administration: I.p.; three times a week for 3 weeks Result: Inhibited the metastasis of breast cancer cells to the lung. Animal Model: Balb/c xenograft model (10-weeks-old female Balb/c mice bearing 4T1 cells) Dosage: 40 mg/kg Administration: I.p.; three times a week for 2.5 weeks Result: Suppressed a lung metastasis in the Balb/c Xenograft model.
IC50& Target:ALK5 4.83 nM (IC 50 ) p38α 1.5 μM (IC 50 )
规格
规格或纯度
10mM in DMSO
英文名称
EW-7195
生化机理
EW-7195 是一种强效、选择性 ALK5（TGFβR1）抑制剂，其 IC 50 为 4.83 nM。与 p38α 相比，EW-7195 对 ALK5 的选择性大于 300 倍。EW-7195 能有效抑制 TGF-β1 诱导的 Smad 信号转导、上皮细胞向间质转化（EMT）和乳腺癌的发生。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
分子量
406.44
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
Copyright © 2023至今 上海阿拉丁生化科技股份有限公司 SSE:688179 保留所有权利。
危险品化学品经营许可证（带存储）