计算溶液所需的质量、体积或浓度。
| 活性类型 | 活性值-log(M) | 作用机制 | 期刊 | 参考文献(PubMed IDs) |
|---|
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
E1R is a positive allosteric modulator of sigma-1 receptors ( Sig1R PAM ) with cognition-enhancing activity.
In Vitro
The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([ 3 H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male ICR and Balb/c mice weighed 23-25 g Dosage: 0.1, 1 and 10 mg/kg Administration: Administered i.p. 60 min before the training session Result: Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.
规格
规格或纯度
10mM in DMSO
英文名称
E1R
生化机理
E1R 是σ-1 受体（Sig1R PAM）的正异位调节剂，具有增强认知的活性。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
激动剂
名称和识别符
技术文档
高级数据
关联靶点（人）
SIGMAR1
Tclin
Sigma 非阿片类细胞内受体 1(Sigma non-opioid intracellular receptor 1)
(1 活性数据)
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
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溶液计算器
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