计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
干燥,-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
概述
Epiberberine chloride is an alkaloid isolated from Coptis chinensis , acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC 50 s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC 50 , 16.83 μM), and may protect against Alzheimer disease Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways Epiberberine has the potential effect in the research of diabetic disease
In Vitro
Epiberberine (0, 12.5, 25, or 50 μM) dose-dependently inhibits cellular triglyceride accumulation in 3T3-L1 adipocytes, with an IC 50 of 52.8 μM. Epiberberine (12.5-50 μM) suppresses the Raf/MEK1/ERK1/2 and AMPKα/Akt pathways in the early stage of 3T3-L1 adipocyte differentiation. Epiberberine (0.2, 1, 5 μg/mL) inhibits glucose uptake in HepG2 cells in a concentration-dependent manner. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Epiberberine (225 mg/kg, p.o. daily for 40 days) reduces body weight, food consumption, water intake, and urinary output of KK-Ay mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:AChE BACE1 BChE
规格
别名
氯化表小檗碱
规格或纯度
10mM in DMSO
英文名称
Epiberberine chloride
生化机理
氯化表小檗碱是从黄连中分离出来的一种生物碱，是一种强效的 AChE 和 BChE 抑制剂，也是一种非竞争性的 BACE1 抑制剂，其 IC 50 s 分别为 1.07、6.03 和 8.55 μM。表小檗碱氯化物具有抗氧化活性，可用于抗氧化剂和抗肿瘤药物。
储存条件
干燥,-80℃储存
运输条件
特低温运输
作用类型
抑制剂
名称和识别符
分子类型
小分子
Isomeric SMILES
COC1=C(C=C2C(=C1)CC[N+]3=C2C=C4C=CC5=C(C4=C3)OCO5)OC.[Cl-]
PubChem CID
分子量
336.363545
技术文档
高级数据
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
溶液计算器
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