BioReagent 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Relatlimab是一种用于治疗黑色素瘤的单克隆抗体，可与nivolumab联合用于治疗黑色素瘤。Relatlimab是一种淋巴细胞活化基因-3（LAG-3）抑制剂。LAG-3是免疫检查点蛋白，其高表达会抑制T细胞活性，促进肿瘤免疫逃逸。Relatlimab以高亲和力和特异性与人 LAG-3 结合，以阻断 LAG-3 与配体 MHC II 和纤维蛋白原样蛋白-1 的相互作用，并逆转 LAG-3 介导的体外 T 细胞功能的抑制。 本试剂盒采用间接法酶联免疫吸附试验（ELISA）。往预先包被有人LAG-3抗原的微孔中，依次加入样本、标准品、HRP标记的二抗，中间经过温育和洗涤，用底物TMB显色，TMB在过氧化物酶(HRP)的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样本中的瑞拉利单抗(Relatlimab)呈正相关。用酶标仪在450nm波长下测定吸光度（OD值），计算样本浓度。
This kit employs the indirect enzyme-linked immunosorbent assay (ELISA) principle. Microplate wells are pre-coated with Human LAG-3 antigen. The sample or standard is first added to the wells, followed by an HRP (horseradish peroxidase)-labeled secondary antibody. The procedure involves incubation and wash steps between each addition. TMB substrate is then added for color development. Under the catalysis of the peroxidase (HRP), TMB is converted into a blue product, which subsequently turns into a final stable yellow color upon the addition of an acid stop solution. The intensity of the yellow color is directly proportional to the concentration of Relatlimab in the sample. The optical density (OD) is measured at a wavelength of 450 nm using a microplate reader, and the concentration of the target analyte in the sample is calculated based on the standard curve.
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