BioReagent 级 ，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
司妥昔单抗（Siltuximab）是一种人源化单克隆抗体，属于白细胞介素-6（IL-6）受体拮抗剂，通过特异性结合IL-6，阻断其与可溶性和膜结合受体的相互作用，从而抑制IL-6介导的信号传导。该药物主要用于治疗HIV阴性和人疱疹病毒8型（HHV-8）阴性的多中心型Castleman病（MCD）成人患者。其作用机制包括抑制炎症反应、调节免疫细胞功能以及减少血管生成，从而缓解疾病症状并改善患者生活质量。 本试剂盒采用间接法酶联免疫吸附试验（ELISA）。往预先包被有人IL-6抗原的微孔中，依次加入样本、标准品、HRP标记的二抗，中间经过温育和洗涤，用底物TMB显色，TMB在过氧化物酶(HRP)的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样本中的司妥昔单抗(Siltuximab)呈正相关。用酶标仪在450nm波长下测定吸光度（OD值），计算样本浓度。
This kit employs the indirect enzyme-linked immunosorbent assay (ELISA) principle. Microplate wells are pre-coated with Human IL-6 antigen. The sample or standard is first added to the wells, followed by an HRP (horseradish peroxidase)-labeled secondary antibody. The procedure involves incubation and wash steps between each addition. TMB substrate is then added for color development. Under the catalysis of the peroxidase (HRP), TMB is converted into a blue product, which subsequently turns into a final stable yellow color upon the addition of an acid stop solution. The intensity of the yellow color is directly proportional to the concentration of Siltuximab in the sample. The optical density (OD) is measured at a wavelength of 450 nm using a microplate reader, and the concentration of the target analyte in the sample is calculated based on the standard curve.
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