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沙巴托利单抗（Sabatolimab）是一种新型人源化IgG4单克隆抗体，靶向T细胞免疫球蛋白黏蛋白3（TIM-3）。TIM-3是一种重要的免疫检查点分子，在多种免疫细胞和肿瘤细胞表面表达，参与调节免疫应答和肿瘤免疫逃逸。沙巴托利单抗通过阻断TIM-3与其配体的相互作用，激活免疫系统，增强T细胞和自然杀伤细胞的抗肿瘤活性，从而抑制肿瘤生长。该药物在急性髓系白血病（AML）和骨髓增生异常综合征（MDS）等血液系统恶性肿瘤的临床试验中显示出良好的疗效和安全性，尤其在联合去甲基化药物（如阿扎胞苷）治疗中，能够延长患者的无进展生存期和总生存期。 本试剂盒采用间接法酶联免疫吸附试验（ELISA）。往预先包被有人TIM-3抗原的微孔中，依次加入样本、标准品、HRP标记的二抗，中间经过温育和洗涤，用底物TMB显色，TMB在过氧化物酶(HRP)的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样本中的沙巴托利单抗(Sabatolimab)呈正相关。用酶标仪在450nm波长下测定吸光度（OD值），计算样本浓度。
This kit employs the indirect enzyme-linked immunosorbent assay (ELISA) principle. Microplate wells are pre-coated with Human TIM-3 antigen. The sample or standard is first added to the wells, followed by an HRP (horseradish peroxidase)-labeled secondary antibody. The procedure involves incubation and wash steps between each addition. TMB substrate is then added for color development. Under the catalysis of the peroxidase (HRP), TMB is converted into a blue product, which subsequently turns into a final stable yellow color upon the addition of an acid stop solution. The intensity of the yellow color is directly proportional to the concentration of Sabatolimab in the sample. The optical density (OD) is measured at a wavelength of 450 nm using a microplate reader, and the concentration of the target analyte in the sample is calculated based on the standard curve.
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