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阿麦妥单抗（Amatuximab）是一种针对细胞表面间皮素（MSLN）的嵌合人源化IgG1/k单抗。间皮素是一种存在于有限正常成人组织中的糖基磷脂酰肌醇（GPI）锚定膜糖蛋白。阿麦妥单抗能够与间皮素特异性结合，阻止细胞分裂，具有抗肿瘤活性，主要用于治疗实体肿瘤。体外实验表明，它能诱导抗体依赖的细胞介导的细胞毒性（ADCC）对抗表达间皮素的肿瘤细胞，并抑制间皮素阳性肿瘤细胞与表达CA125的肿瘤细胞之间的异型细胞粘连。在肿瘤异种移植模型研究中，阿麦妥单抗与化疗的联合治疗比单独使用更能显著降低肿瘤生长。 本试剂盒采用间接法酶联免疫吸附试验（ELISA）。往预先包被有人mesothelin抗原的微孔中，依次加入样本、标准品、HRP标记的二抗，中间经过温育和洗涤，用底物TMB显色，TMB在过氧化物酶(HRP)的催化下转化成蓝色，并在酸的作用下转化成最终的黄色。颜色的深浅和样本中的阿麦妥单抗(Amatuximab)呈正相关。用酶标仪在450nm波长下测定吸光度（OD值），计算样本浓度。
This kit employs the indirect enzyme-linked immunosorbent assay (ELISA) principle. Microplate wells are pre-coated with Human Mesothelin antigen. The sample or standard is first added to the wells, followed by an HRP (horseradish peroxidase)-labeled secondary antibody. The procedure involves incubation and wash steps between each addition. TMB substrate is then added for color development. Under the catalysis of the peroxidase (HRP), TMB is converted into a blue product, which subsequently turns into a final stable yellow color upon the addition of an acid stop solution. The intensity of the yellow color is directly proportional to the concentration of Amatuximab in the sample. The optical density (OD) is measured at a wavelength of 450 nm using a microplate reader, and the concentration of the target analyte in the sample is calculated based on the standard curve.
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