FGFR-IN-8 (Compound 17a) is a highly potent and orally active pan FGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC 50 values of <0.5, 189.1, <0.5, 22.6, <0.5 and 7.30 nM against FGFR1 , V564F-FGFR2, N549H-FGFR2, V555M-FGFR3, FGFR3 and FGFR4 , respectively. GFR-IN-8 induces cancer cell apoptosis and shows anticancer activities.