FLT3/CHK1-IN-2 (Compound 30) is a dual inhibitor of FLT3 and CHK1 , with IC 50 s of 25.63, 16.39, 22.80 nM for CHK1 , FLT3-WT, and FLT-D835Y respectively. FLT3/CHK1-IN-2 has favorable oral PK properties and kinase selectivity. FLT3/CHK1-IN-2 can be used for research of acute myeloid leukemia (AML).