FGFR-IN-10 is an orally active inhibitor of FGFR and Cytochrome P450 ( CYPs ). FGFR-IN-10 inhibits wide type and V564F mutant FGFR2 with IC 50 s of 104.1 nM and 43.6 nM, respectively. FGFR-IN-10 also inhibits CYPs with IC 50 s of 3.33 μM ( CYP2C9 ), 18.75 μM ( CYP2C19 ), 4.34 μM (CYP2CD6), and 0.69 μM ( CYP3A4 ), respectively.