FGFR-IN-14 (compound 10h) is a pan-FGFR inhibitor. FGFR-IN-14 inhibits FGFR1 , FGFR2 , FGFR3 and FGFR2 V564F gatekeeper mutant with IC 50 s of 46, 41, 99, and 62 nM, respectively. FGFR-IN-14 strongly suppresses NCI-H520 lung cancer cells, SNU-16 and KATO III gastric cancer cells proliferation with IC 50 s of 19, 59, and 73 nM, respectively.