计算溶液所需的质量、体积或浓度。
为什么选择此级别
，适用于对基线干扰要求严格的色谱和分析工作流程。
储存与运输
-80℃储存。特低温运输 。请查阅批次 COA 获取详细规格。
质量文档
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
文献证明
在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
概述
Information
Fenoprofen calcium hydrate is a non-steroidal anti-inflammatory drug (NSAID).
In vitro
Fenoprofen is a more potent inhibitor of collagen-induced platelet aggregation than either aspirin or phenylbutazone. Fenoprofen inhibits the formation of palmitoyl-CoA in both microsomal and peroxisomal fractions, and inhibits the beta-oxidation of lignoceric acid and cerotic acid in rat hepatocytes. Fenoprofen exhibits modest antiproliferative activity against HT-29, DID-1, and SW480 cells with IC50 of 240 μM, 300 μM, and 360 μM, respectively. Fenoprofen (0.1 mM) is an efficient activator of peroxisome proliferator-activated receptor gamma (PPARγ), activating the receptor to a degree comparable to that obtained with the PPARγ ligands BRL49653 and 15-deoxy-D12,14-PGJ2 and the peroxisome proliferator Wy14643. Fenoprofen is also an efficacious activator of PPARα, activating the receptor to a degree comparable to that obtained with the strong peroxisome proliferator Wy14643. Consistently, Fenoprofen treatment promotes lipogenesis in C3H10T1/2 cells. Although Fenoprofen displays only modest antiproliferative activity, Fenoprofen amides can potently induce cell cycle arrest at the G1 phase, as well as apoptosis, probably because of a greater lipophilicity and/or better cell uptake.
In vivo
Oral administration of Fenoprofen at 50 mg/kg potently inhibits thrombus formation by 47%, whereas a dose of 200 mg/kg of aspirin is required to reduce thrombus formation 21 %. Similar to indomethacin, adminstration of Fenoprofen inhibits prostaglandin synthesis. In rats with type II collagen-induced arthritis, Fenoprofen treatment at 40 mg/kg/day partially suppresses the paw swelling, but has no significant effect on humoral and cellular responses. Administration of Fenoprofen depresses the rebound contraction, thus transforming the brisk relaxant response, elicited by vagal stimulation or ATP, into long-lasting relaxation. Administration of Fenoprofen causes a strong and dose-related induction of peroxisomal palmitoyl-CoA oxidase, and of carnitine acyltransferase and acyl-CoA hydrolase activities in liver homogenates of mice fed diets. Hepatic catalase activity is significantly increased in mice fed the diet with 0.05 and 0.1% fenoprofen but not the 1% fenoprofen-containing diet.
Cell Data
cell lines：
Concentrations：Dissolved in DMSO, final concentrations ~1 mM
Incubation Time：6 days
Powder Purity:≥99%
规格
英文别名
α-methyl-3-phenoxy-benzeneacetic acid, calcium salt, hydrate (2:1:2)
规格或纯度
10mM in DMSO
英文名称
Fenoprofen calcium hydrate
生化机理
非诺洛芬钙水合物是一种非甾体抗炎药（NSAID）。
储存条件
-80℃储存
运输条件
特低温运输
作用类型
抑制剂
作用机制
环氧化酶抑制剂
名称和识别符
EC号
672-650-9
分子类型
小分子
Isomeric SMILES
CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].CC(C1=CC(=CC=C1)OC2=CC=CC=C2)C(=O)[O-].O.O.[Ca+2]
分子量
242.27
Reaxy-Rn
7614244
Reaxys-RN link address
https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=7614244&ln=
技术文档
高级数据
安全和危险性（GHS）
象形图
信号词
Warning
危险声明
H302: 吞食有害
H312: 皮肤接触有害
H332: 吸入有害
预防措施声明
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾
P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。
P302+P352: 如皮肤沾染：用水充分清洗。
P321: 特殊处理（请参阅此标签上的...）。
P501: 将内容物/容器处理到。。。
P264: 处理后要彻底洗手。
P271: 仅在室外或通风良好的地方使用。
P270: 使用本产品时，请勿进食、饮水或吸烟。
P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。
P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。
P330: 漱口
P301+P317: 如果被吞咽：请寻求医疗帮助。
P317: 寻求紧急医疗救助。
RTECS
CY1678900
Merck Index
3980
质检证书（CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:
此产品的引用文献
溶液计算器
常见问题
本产品应如何储存？
请于?80 °C条件下保存。需超低温保存以维持规定的有效期。
本产品如何运输？
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包，并按上述储存条件保存；处理干冰时请戴隔热手套并保持通风。
本产品的 CAS 号、分子式和分子量是多少？
本产品的 CAS 号为 71720-56-4，分子式为 C15H14O3·1/2Ca·H2O，分子量为 242.27 g/mol。
如何获取批次专用COA？
每个订单都会随附分析证书（COA），您也可以从账户订单历史中下载。如需订购前的COA，请联系您的客户代表，或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
产品仅提供给经过验证的企业、机构和合格的专业人员用于研发。不适用于人类、动物、诊断或治疗。
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