| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| F420391-1ml |
1ml |
现货  |
|
| 英文别名 | EN300-114143 | SCHEMBL25491 | Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- | Fadrozol [INN-Spanish] | A23588 | FAD 286 | GTPL8311 | DTXSID5034141 | 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine | 4-(5,6,7,8-tetrahydroimidazo[ |
|---|---|
| 规格或纯度 | Moligand™, 10mM in DMSO |
| 英文名称 | Fadrozole (CGS16949A) |
| 生化机理 | 法卓唑（CGS16949A）是一种强效、选择性、非甾体类芳香化酶抑制剂，其 IC50 值为 4.5 nM，对其他细胞色素 P-450 酶具有选择性。 |
| 储存温度 | -80℃储存 |
| 运输条件 | 超低温冰袋运输 |
| 作用类型 | 抑制剂 |
| 作用机制 | CYP11B1 抑制剂;CYP11B2 抑制剂;CYP19A1 抑制剂 |
| 产品介绍 |
Fadrozole (CGS 16949A free base) 是一种有效，选择性和非甾体类的 aromatase 抑制剂，IC50 值为6.4 nM。
Information Fadrozole (CGS16949A) Fadrozole (CGS16949A) is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes. Targets Aromatase 4.5 nM |
| ALogP | 2.271 |
|---|---|
| hba_count | 1 |
| Rotatable Bond | 1 |
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| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
| 分子类型 | 小分子 |
|---|---|
| IUPAC Name | 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile |
| INCHI | InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2 |
| InChi Key | CLPFFLWZZBQMAO-UHFFFAOYSA-N |
| Canonical SMILES | C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N |
| Isomeric SMILES | C1CC(N2C=NC=C2C1)C3=CC=C(C=C3)C#N |
| 分子量 | 223.27 |
| Reaxy-Rn | 4294957 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4294957&ln= |
| DMSO(mg / mL) Max Solubility | 45 |
|---|---|
| DMSO(mM) Max Solubility | 201.549693196578 |
| Water(mg / mL) Max Solubility | ＜1 |
| 分子量 | 223.270 g/mol |
| XLogP3 | 2.100 |
| 氢键供体数Hydrogen Bond Donor Count | 0 |
| 氢键受体数Hydrogen Bond Acceptor Count | 2 |
| 可旋转键计数Rotatable Bond Count | 1 |
| 精确质量Exact Mass | 223.111 Da |
| 单同位素质量Monoisotopic Mass | 223.111 Da |
| 拓扑极表面积Topological Polar Surface Area | 41.600 Ų |
| 重原子数Heavy Atom Count | 17 |
| 形式电荷Formal Charge | 0 |
| 复杂度Complexity | 311.000 |
| 同位素原子数Isotope Atom Count | 0 |
| 定义的原子立体中心计数Defined Atom Stereocenter Count | 0 |
| 未定义的原子立体中心计数Undefined Atom Stereocenter Count | 1 |
| 定义的键立体中心计数Defined Bond Stereocenter Count | 0 |
| 未定义的键立体中心计数Undefined Bond Stereocenter Count | 0 |
| 所有立体化学键的总数The total count of all stereochemical bonds | 0 |
| 共价键合单元计数Covalently-Bonded Unit Count | 1 |
| 象形图 | GHS07 |
|---|---|
| 信号词 | Warning |
| 危险声明 |
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H312: 皮肤接触有害 H332: 吸入有害 |
| 预防措施声明 |
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良好的地方。保持容器密闭。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。 P332+P317: 如果出现皮肤刺激：请寻求医疗帮助。 P319: 如果你感到不适，请寻求医疗帮助。 |
| Reaxy-Rn | 4294957 |
| Reaxys-RN link address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4294957&ln= |
| Concentration(Compounding value) | 9-11(mmol/L) |
|---|---|
| Record the entire process by video | Conform |
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