Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine ( HY-B0069 ), is a potent, noncompetitive and specific inhibitor of DNA primase , with an IC 50 of 2.3 μM and a K i of 6.1 μM. Fludarabine triphosphate trisodium inhibits
In Vitro:Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells. Fludarabine triphosphate trisodium (10-50 μM) inhibits
Biological Activity:Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine ( HY-B0069 ), is a potent, noncompetitive and specific inhibitor of DNA primase , with an IC 50 of 2.3 μM and a K i of 6.1 μM. Fludarabine triphosphate trisodium inhibits