1-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)ethan-1-amine: FAQs
1-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)ethan-1-amine: FAQs
1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine is a bicyclic heterocyclic primary amine featuring a [1,2,4]triazolo[4,3-a]pyridine core bearing a 1-aminoethyl substituent at the 3-position, valued as a versatile building block in medicinal chemistry and drug-discovery research.
- Chemical Name
- 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine
- Aladdin SKU
- E692642
- Compound Class
- Bicyclic heterocyclic primary amine (triazolopyridine scaffold)
- Key Functional Groups
- Primary amine, triazole ring, pyridine ring
- Typical Application
- Medicinal chemistry building block, fragment-based drug discovery, scaffold synthesis
- Storage Recommendation
- Store in a cool, dry, well-ventilated area away from moisture and light; confirm exact conditions on CoA
What Is 1-([1,2,4]Triazolo[4,3-a]pyridin-3-yl)ethan-1-amine?
1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine is a bicyclic nitrogen-rich heterocyclic compound consisting of a [1,2,4]triazolo[4,3-a]pyridine ring system substituted at the 3-position with a 1-aminoethyl group. The fused triazole-pyridine scaffold is a privileged structure in medicinal chemistry because it confers favorable physicochemical properties—including moderate polarity, hydrogen-bond donor/acceptor capacity, and metabolic stability—that are desirable in drug-like molecules.
The compound contains a chiral center at the carbon bearing the primary amine, making it relevant to asymmetric synthesis and the preparation of enantiomerically enriched intermediates. Researchers use it as a versatile building block in the construction of more complex molecules targeting a range of biological pathways.
Physical and Chemical Properties: Common Questions
What is the molecular formula and molecular weight? The molecular formula is C8H10N4, giving a molecular weight of approximately 162.19 g/mol. Please verify these values against the current Certificate of Analysis (CoA) provided with each lot.
Is the compound stable at room temperature? As a primary amine adjacent to a heteroaromatic system, the compound may be susceptible to oxidation and moisture uptake over extended periods. It is advisable to store the compound under the conditions specified on the CoA and to minimize exposure to air during weighing.
What solvents is it soluble in? Triazolopyridine amines of this class are generally soluble in polar aprotic solvents such as DMSO and DMF, and in protic solvents such as methanol and water (especially at slightly acidic pH due to protonation of the amine). Solubility in non-polar solvents such as hexane is expected to be low. Always confirm solubility empirically for your specific application.
Handling, Safety, and Storage
What personal protective equipment (PPE) is required? As with all primary amines and nitrogen heterocycles, standard laboratory PPE should be used: nitrile gloves, safety goggles, and a laboratory coat. Work in a fume hood when weighing or dissolving the compound to avoid inhalation of dust or vapors.
How should the compound be stored? Store in a tightly sealed container in a cool, dry location away from direct light, heat sources, and incompatible materials (strong oxidizers, strong acids). Refer to the Safety Data Sheet (SDS) and CoA supplied by Aladdin Scientific for lot-specific storage temperature recommendations.
What is the shelf life? Shelf life is lot-dependent and specified on the CoA. To maximize stability, avoid repeated freeze-thaw cycles if the material is stored frozen, and re-seal the container promptly after each use.
Purity, Quality, and Analytical Data
What purity grade is offered by Aladdin Scientific? Aladdin Scientific supplies 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine (SKU E692642) as a research-grade reagent. The specific purity value and analytical data (e.g., HPLC, NMR) for each lot are documented on the Certificate of Analysis available upon request or at the time of order.
What analytical methods are used to characterize the compound? Typical characterization methods for building blocks of this class include high-performance liquid chromatography (HPLC) for purity determination, 1H and 13C nuclear magnetic resonance (NMR) spectroscopy for structural confirmation, and mass spectrometry (MS) for molecular weight verification. Chiral purity, if relevant, may be assessed by chiral HPLC.
Can a Certificate of Analysis be provided? Yes. A lot-specific CoA is available for every batch of E692642. Contact Aladdin Scientific customer service or download the CoA directly from the product page on the Aladdin website.
Ordering and Applications
How can I order E692642? 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine (SKU E692642) can be ordered directly through the Aladdin Scientific website, by contacting your regional Aladdin sales representative, or via your institution's approved procurement platform. Bulk quantities and custom pack sizes may be available upon request.
What are the primary research applications? This compound is primarily used as a synthetic building block and intermediate in medicinal chemistry programs. Its triazolopyridine scaffold makes it attractive for fragment-based drug discovery, the preparation of kinase inhibitor candidates, and the construction of libraries for high-throughput screening. The primary amine functionality allows coupling with carboxylic acids (amide bond formation), aldehydes (reductive amination), and electrophiles, enabling rapid structural diversification.
Is technical support available? Yes. Aladdin Scientific's technical team can assist with questions related to compound identity, handling recommendations, and documentation. Contact us via the website or customer service hotline for prompt assistance.
Frequently asked questions
What is the CAS number for 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine?
The CAS registry number for this compound should be confirmed on the current Certificate of Analysis or product page, as CAS numbers can vary for different salt forms or enantiomers. Contact Aladdin Scientific customer service for the exact CAS number associated with SKU E692642.
Is 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine available as a single enantiomer?
The compound contains a chiral center and may be offered as a racemate or as individual enantiomers depending on current stock and manufacturing. Please contact Aladdin Scientific directly to inquire about enantiopure forms, chiral purity data, or custom synthesis options for E692642.
What coupling reactions are suitable for the primary amine group of this compound?
The primary amine is well-suited for standard synthetic transformations including amide bond formation with activated carboxylic acids or acid chlorides, reductive amination with aldehydes or ketones, sulfonamide formation with sulfonyl chlorides, and Buchwald-Hartwig cross-coupling. These reactions enable rapid diversification of the triazolopyridine scaffold for SAR studies.
How should I prepare a stock solution of this compound for biological assays?
For biological assays, dissolve the compound in DMSO to prepare a concentrated stock solution (e.g., 10–100 mM), then dilute into the aqueous assay buffer immediately before use to minimize DMSO concentration (typically ≤0.1–1% v/v in final assay). Confirm solubility and stability in your specific buffer system experimentally, and filter-sterilize if required for cell-based assays.
What documentation is available to support GMP or regulated research requirements?
Aladdin Scientific provides a Certificate of Analysis and Safety Data Sheet for each lot of E692642. These documents support research-grade procurement and quality review. For GMP-grade material or additional regulatory documentation, please contact Aladdin Scientific to discuss custom supply options.
References
- Aladdin Scientific Product Page: 1-([1,2,4]triazolo[4,3-a]pyridin-3-yl)ethan-1-amine, SKU E692642.
- Lipinski, C. A. et al. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced Drug Delivery Reviews, 2001. doi:10.1016/s0169-409x(00)00129-0
- Meanwell, N. A. Synopsis of some recent tactical application of bioisosteres in drug design. Journal of Medicinal Chemistry, 2011. doi:10.1021/jm1013898
Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.
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