Reagent Overview and Properties

1-(2-Fluoropyridin-4-yl)ethan-1-one (SKU: E727681) is a heterocyclic aromatic ketone featuring a pyridine ring substituted with a fluorine atom at the 2-position and an acetyl group at the 4-position. The molecular formula is C₇H₆FNO with a molecular weight of approximately 139.13 g/mol.

The presence of both an electron-withdrawing fluorine substituent and a carbonyl group makes this compound particularly reactive in nucleophilic aromatic substitution (SNAr) reactions and condensation chemistry. It is valued in pharmaceutical and agrochemical synthesis as a versatile electrophilic building block for constructing nitrogen-containing heterocyclic frameworks.

Note: Confirm exact physical form, purity, and CAS number against the Certificate of Analysis (CoA) supplied with the product lot.

Safety and Handling Precautions

Handle 1-(2-Fluoropyridin-4-yl)ethan-1-one in accordance with standard laboratory safety practices for reactive organic intermediates. The following precautions are recommended:

• Personal Protective Equipment (PPE): Wear chemically resistant gloves (nitrile or neoprene), safety goggles, and a lab coat. Work in a well-ventilated fume hood.
• Skin and Eye Contact: Avoid direct contact. In case of skin contact, wash thoroughly with soap and water. For eye contact, rinse immediately with copious water and seek medical attention.
• Inhalation: Avoid breathing vapors or dust. Use a fume hood when weighing or dissolving the compound.
• Flammability: Treat as a potentially flammable organic compound; keep away from open flames and strong oxidizers.
• Regulatory Compliance: Consult the Safety Data Sheet (SDS) for full hazard classification (GHS), first-aid measures, and disposal regulations applicable to your jurisdiction.

Review flag: Full GHS hazard categories and H/P statements must be verified against the official SDS for lot E727681.

Dissolution, Preparation, and Storage

Recommended Solvents: 1-(2-Fluoropyridin-4-yl)ethan-1-one is expected to be soluble in common polar aprotic solvents such as DMSO, DMF, acetonitrile, and dichloromethane, as well as in ethyl acetate. Aqueous solubility is anticipated to be limited; verify solubility experimentally for your specific application.

Stock Solution Preparation:

1. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation on the compound.
2. Weigh the required amount using an analytical balance in a fume hood.
3. Add the appropriate solvent gradually and mix gently (vortex or stir) until fully dissolved.
4. Filter through a 0.2 µm PTFE syringe filter if a particle-free solution is required.

Storage Conditions: Store the compound in a tightly sealed container, protected from light and moisture, at 2–8 °C or as specified on the product label and CoA. For long-term storage, consider storage under inert atmosphere (argon or nitrogen).

Stability: As an aromatic ketone bearing an electron-deficient pyridine ring, the compound is expected to be stable under recommended storage conditions; however, prolonged exposure to air, moisture, or light may cause degradation. Verify stability data with the product CoA.

Review flag: Specific solubility values, melting/boiling points, and confirmed storage temperature must be sourced from the official CoA or SDS.

Typical Research Applications

1-(2-Fluoropyridin-4-yl)ethan-1-one serves as a key electrophilic building block in synthetic and medicinal chemistry. Representative applications include:

• Nucleophilic Aromatic Substitution (SNAr): The fluorine at the electron-deficient 2-position of the pyridine ring is activated toward displacement by amines, thiols, and alkoxides, enabling rapid construction of diverse N-, S-, and O-linked pyridine derivatives.
• Condensation Reactions: The acetyl group participates in aldol, Knoevenagel, and related condensations to yield α,β-unsaturated carbonyl intermediates or heterocyclic products.
• Drug Discovery: Used as a scaffold fragment for the preparation of bioactive molecules, particularly kinase inhibitors and other therapeutics incorporating fluorinated pyridine motifs.
• Agrochemical Synthesis: Serves as an intermediate in the preparation of crop-protection agents containing pyridine cores.
• Cross-Coupling Chemistry: The ketone and fluorine functionalities may be leveraged in metal-catalyzed cross-coupling sequences after appropriate activation or protection.

Review flag: Specific literature references demonstrating biological activity or yields in the above reaction classes should be cited when available.

Quality, Purity, and Ordering Information

Specification: The purity specification and analytical data (e.g., HPLC purity, NMR, GC) for 1-(2-Fluoropyridin-4-yl)ethan-1-one are provided on the Certificate of Analysis (CoA) accompanying each lot. Please request the CoA at time of ordering or download it from the Aladdin Scientific website using the lot number.

Available Pack Sizes: Contact Aladdin Scientific or visit the product page for current available quantities and pricing.

Ordering:

• SKU: E727681
• Product Name: 1-(2-Fluoropyridin-4-yl)ethan-1-one
• Orders may be placed online, by email, or through your local Aladdin Scientific distributor.

Returns and Quality Concerns: If the product does not meet specification, contact Aladdin Scientific customer service with the lot number and CoA within the return window specified in our Returns and Refunds policy.