Chemical Identity and Structure

1,3,5-Trichloro-2-(chloromethyl)benzene is an aromatic compound with the molecular formula C₇H₄Cl₄. Its structure consists of a benzene ring substituted at the 1, 3, and 5 positions with chlorine atoms, and at the 2 position with a chloromethyl (–CH₂Cl) group. The three ring chlorines reduce electron density on the aromatic ring, while the benzylic –CH₂Cl group provides a distinct and highly reactive electrophilic site. This combination of features distinguishes it from simple benzyl chlorides and makes it a useful building block for constructing complex halogenated architectures.

Note: The exact CAS number and confirmed physical constants (melting point, boiling point, density) are not available in the current source material and should be verified against the certificate of analysis (CoA) or a primary chemical database before use.

Common Research and Synthetic Applications

The benzylic chloride moiety in 1,3,5-Trichloro-2-(chloromethyl)benzene is susceptible to nucleophilic substitution reactions (S_N2), enabling coupling with amines, thiols, alcohols, and carbon nucleophiles. Typical applications include:

• Synthesis of polychlorinated benzyl derivatives for use as pharmaceutical intermediates or agrochemical precursors.
• Construction of ether and thioether linkages via reaction with alcohols or thiols under mild base conditions.
• Polymer and materials chemistry, where multi-halogenated arenes serve as crosslinkers or monomers.
• Friedel–Crafts type reactions mediated by Lewis acids, exploiting both the benzylic chloride and the electron-poor aromatic ring.

Researchers should verify applicability for their specific transformation, as the three ring-bound chlorines significantly modulate reactivity relative to unsubstituted benzyl chloride.

Safe Handling, Storage, and Regulatory Considerations

As a polychlorinated benzyl chloride, this compound should be treated with appropriate caution:

• Personal protective equipment (PPE): Wear chemical-resistant gloves, a lab coat, and safety goggles. Work in a well-ventilated fume hood, as benzylic chlorides are potential lachrymators and skin/mucous membrane irritants.
• Storage: Store in a tightly sealed container in a cool, dry location away from moisture, light, and incompatible nucleophiles or bases. Exact recommended temperature range should be confirmed from the product CoA.
• Waste disposal: Dispose of halogenated waste according to your institution's chemical waste management procedures and local regulations.
• SDS review: Consult the Safety Data Sheet (SDS) supplied with SKU T690931 before first use for authoritative hazard, first-aid, and disposal information.

Specific GHS hazard classifications and H/P statements for this product should be taken directly from the official SDS, not from this document.

Purity, Quality, and Ordering Information

Aladdin Scientific supplies 1,3,5-Trichloro-2-(chloromethyl)benzene under SKU T690931. When evaluating suitability for your research:

• Purity specification: Confirm the stated purity grade from the current product listing or CoA. Typical analytical methods for halogenated arenes include GC or HPLC purity determination and NMR identity confirmation.
• Lot-specific CoA: Request a lot-specific certificate of analysis to verify identity (NMR, MS), purity, and appearance before use in sensitive reactions.
• Pack sizes and pricing: Contact Aladdin Scientific or check the online catalog for available quantities, current pricing, and lead times.
• Custom quantities: For bulk or custom packaging requirements, contact the Aladdin Scientific sales team directly.

Purity values and available pack sizes are not stated in the current source material and must be confirmed from the live product page or by contacting customer support.