Chemical Identity and Structure

1-(4-Amino-3-methoxyphenyl)ethanone (CAS number subject to verification; SKU E728593) is a substituted acetophenone in which the para-position of the phenyl ring carries a primary amino group (–NH2) and the meta-position carries a methoxy group (–OCH3). The molecular formula is C₉H₁₁NO₂ and the molecular weight is approximately 165.19 g/mol.

The coexistence of an electron-donating amino group and an electron-donating methoxy group on the aromatic ring significantly activates the ring toward electrophilic substitution, while the amino group also provides a reactive handle for condensation, acylation, diazotization, and reductive amination reactions.

Physical Properties and Storage

1-(4-Amino-3-methoxyphenyl)ethanone is typically obtained as a solid at room temperature. Exact melting point, solubility, and appearance data should be confirmed from the certificate of analysis (CoA) supplied with each lot (SKU E728593).

General guidance for similar aromatic amines recommends storage in a cool, dry, well-ventilated location away from light, oxidizers, and moisture. The container should be kept tightly sealed. Where lot-specific stability data are not available, storage at 2–8 °C under an inert atmosphere (nitrogen or argon) is a conservative best practice to prevent oxidation of the amine functionality.

Always consult the Safety Data Sheet (SDS) for current hazard classification, personal protective equipment (PPE) requirements, and disposal instructions before handling.

Research and Synthetic Applications

The combination of an aryl ketone, a free amine, and a methoxy group in a single scaffold makes 1-(4-Amino-3-methoxyphenyl)ethanone a valuable intermediate in several areas:

• Pharmaceutical synthesis: The aromatic amine can be elaborated via diazotization-coupling, Buchwald–Hartwig amination, or direct condensation to build heterocyclic drug candidates.
• Dye and pigment chemistry: Free arylamines are classical precursors to azo dyes through diazotization.
• Materials science: Acetophenone-derived building blocks are incorporated into conjugated polymers and liquid-crystal materials.
• Bioconjugation probes: The ketone carbonyl can participate in oxime or hydrazone ligation strategies used in chemical biology.

Specific literature references should be verified independently; see the review flags for details.

Handling, Safety, and Regulatory Notes

As with most aromatic amines, 1-(4-Amino-3-methoxyphenyl)ethanone should be handled with appropriate caution. Standard laboratory PPE—nitrile gloves, safety glasses, and a lab coat—should be worn at all times. Work in a fume hood to avoid inhalation of dust or vapors.

Aromatic amines as a class may present sensitization or toxicity risks; however, specific toxicological data for this compound should be obtained from the Aladdin Scientific SDS for SKU E728593. Researchers should comply with all local, national, and institutional regulations governing the use and disposal of chemical reagents.

For spill management, absorb with an inert material, collect in a sealable container, and dispose according to applicable waste regulations. Do not flush to drain.

Ordering and Quality Information

1-(4-Amino-3-methoxyphenyl)ethanone is available from Aladdin Scientific under SKU E728593. Each shipment is accompanied by a certificate of analysis (CoA) documenting purity, lot number, and analytical data.

For bulk quantities, custom packaging, or questions about specifications and grades, contact Aladdin Scientific technical support or your regional sales representative. Pricing, availability, and lead times can be confirmed through the Aladdin online catalog or procurement team.

Returns, refunds, and shipping queries should be directed to Aladdin customer service in accordance with the company's standard policies.